TITLE ICa for horizontal cell
: Calcium current (ICa) for horizontal cells
:
: Based on parameters of Aoyama et al. (2000)
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX HzICa
USEION ca WRITE ica
RANGE gbar
RANGE m_inf
RANGE tau_m
RANGE m_exp
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gbar = 8.4906e-05 (mho/cm2) : 9 ns total
eca = 53.040 (mV) : 2 mM outside, 30 uM inside
}
STATE {
m
}
ASSIGNED {
v (mV)
ica (mA/cm2)
celsius (degC)
dt (ms)
m_inf
tau_m
m_exp
tadj
}
BREAKPOINT {
SOLVE states
ica = gbar * m*m*m*m * (v - eca)
}
PROCEDURE states() {
: exact when v held constant
evaluate_fct(v)
m = m + m_exp * (m_inf - m)
}
UNITSOFF
INITIAL {
m = 0.059
tadj = 3.0 ^ ((celsius-25)/10) : correction for physio temp
}
PROCEDURE evaluate_fct(v(mV)) { LOCAL a, b, v2
a = (240 * (68-v)) / ( exp( (68-v)/21 ) - 1)
b = 800 / ( exp( (55+v)/55 ) + 1 )
tau_m = 1 / (a + b) / tadj
m_inf = a / (a + b)
m_exp = 1 - exp(-dt/tau_m)
}
UNITSON