<?xml version="1.0" encoding="UTF-8"?> <channelml xmlns="http://morphml.org/channelml/schema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:meta="http://morphml.org/metadata/schema" xsi:schemaLocation="http://morphml.org/channelml/schema http://www.neuroml.org/NeuroMLValidator/NeuroMLFiles/Schemata/v1.8.1/Level2/ChannelML_v1.8.1.xsd" units="SI Units"> <meta:notes>A channel from Maex, R and De Schutter, E. Synchronization of Golgi and Granule Cell Firing in a Detailed Network Model of the Cerebellar Granule Cell Layer</meta:notes> <channel_type name="Gran_CaHVA_98"> <status value="stable"> <meta:comment>Verified equivalence of NEURON and GENESIS mapping to orig GENESIS impl from www.tnb.ua.ac.be.</meta:comment> <meta:comment>Updated to post v1.7.3 new ChannelML format</meta:comment> <meta:contributor> <meta:name>Padraig Gleeson</meta:name> </meta:contributor> </status> <meta:notes>A High Voltage Activated Ca2+ channel</meta:notes> <meta:authorList> <meta:modelAuthor> <meta:name>Maex, R.</meta:name> </meta:modelAuthor> <meta:modelAuthor> <meta:name>De Schutter, E.</meta:name> </meta:modelAuthor> <meta:modelTranslator> <meta:name>Padraig Gleeson</meta:name> <meta:institution>UCL</meta:institution> <meta:email>p.gleeson - at - ucl.ac.uk</meta:email> </meta:modelTranslator> </meta:authorList> <meta:publication> <meta:fullTitle>Maex, R and De Schutter, E. Synchronization of Golgi and Granule Cell Firing in a Detailed Network Model of the cerebellar Granule Cell Layer. J Neurophysiol, Nov 1998; 80: 2521 - 2537</meta:fullTitle> <meta:pubmedRef>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9819260&dopt=Abstract</meta:pubmedRef> </meta:publication> <meta:neuronDBref> <meta:modelName>Calcium channels</meta:modelName> <meta:uri>http://senselab.med.yale.edu/senselab/NeuronDB/channelGene2.htm#table1</meta:uri> </meta:neuronDBref> <current_voltage_relation cond_law="ohmic" ion="ca" default_gmax="9.084216" default_erev="0.080" charge="2" fixed_erev="yes"> <!-- In the orig model, [Ca] alterations didn't alter erev for channel from 80mV --> <q10_settings q10_factor="3" experimental_temp="17.350264793"/> <offset value="0.010"/> <gate name="m" instances="2"> <closed_state id="m0"/> <open_state id="m"/> <transition name="alpha" from="m0" to="m" expr_form="sigmoid" rate="1600" scale="-0.01388888889" midpoint="0.005" /> <transition name="beta" from="m" to="m0" expr_form="exp_linear" rate="100" scale="-0.005" midpoint="-0.0089" /> </gate> <gate name="h" instances="1"> <closed_state id="h0"/> <open_state id="h"/> <!-- Aditya removed the "condition; iftrue; iffalse" type of expression, as it is not a valid python expression --> <transition name="alpha" from="h0" to="h" expr_form="generic" expr="5 * (exp (-50 * (v - (-0.060))))" /> <transition name="beta" from="h" to="h0" expr_form="generic" expr="5 - (5 * (exp (-50 * (v - (-0.060)))))" /> </gate> </current_voltage_relation> </channel_type> </channelml>