#!/usr/bin/env python
# -*- coding: utf-8 -*-
import os
import sys
import math
# The PYTHONPATH should contain the location of moose.py and _moose.so
# files. Putting ".." with the assumption that moose.py and _moose.so
# has been generated in ${MOOSE_SOURCE_DIRECTORY}/pymoose/ (as default
# pymoose build does) and this file is located in
# ${MOOSE_SOURCE_DIRECTORY}/pymoose/examples
# sys.path.append('..\..')
try:
import moose
except ImportError:
print "ERROR: Could not import moose. Please add the directory containing moose.py in your PYTHONPATH"
import sys
sys.exit(1)
from channelConstants import *
VKCa = -80.0e-3 # Volts # kca3.mod has a vshift=-10mV in addition to ek=-70mV
GKCa = 142.0*sarea # Siemens, from mit4.hoc
def calc_KCa_PG_alpha_y(v,Ca):
#return math.exp((v-65e-3)/27e-3) * 500.0e3*(0.015-Ca)/(math.exp((0.015-Ca)/0.0013)-1) # This is from Bhalla and Bower's 1993 paper: perhaps the v-65e-3 is a typo. It should be as below.
#return math.exp((v+70e-3)/27e-3)*1e3 * 500.0*(0.015-Ca)/(math.exp((0.015-Ca)/0.0013)-1) # This is from kca3.mod: different from Bhalla and Bower 1993 paper. see above
## Changed the Ca half point for the PG cell as I reduced B by 100 to get intracellular Ca conc to reasonable levels.
return math.exp((v+70e-3)/27e-3)*1e3 * 500.0*(0.0055-Ca)/(math.exp((0.0055-Ca)/0.0013)-1)
def calc_KCa_PG_beta_y(v,Ca):
return 0.05e3
CaMIN = 0.0
CaMAX = 1.0e-2 # mol/m^2 same as millimol/litre
CaNDIVS = 100
class KCaChannel_PG(moose.HHChannel2D):
"""KCa_PG channel inherits from HHChannel2D."""
def __init__(self, *args):
"""Setup the KCa channel with defaults"""
moose.HHChannel2D.__init__(self,*args)
### Since this channel is table based and this script is for creation of KCaA_PG.dat and KCaB_PG.dat,
### while KCaMPIChannel_PG.py is for reading in these tables,
### we hard code the VMIN, VMAX and NDIVS so that those in globalConstants.py
### do not spoil the reading in of already created tables.
VMIN = -0.1 # V
VMAX = 0.05 # V
NDIVS = 150
dv = (VMAX-VMIN)/NDIVS
## For HHChannel2D Ek, Gbar, etc don't get set via python assignments!!!
## Have to use moose shell commands.
#self.Ek = VKCa
self.getContext().runG('setfield '+self.path+' Ek '+str(VKCa))
#self.Gbar = GKCa
self.getContext().runG('setfield '+self.path+' Gbar '+str(GKCa))
self.addField('ion')
self.setField('ion','K')
self.addField('ionDependency')
self.setField('ionDependency','Ca')
## This will create HHGate2D instance xGate inside the KCa channel.
## (2D since it is within HHChannel2D)
self.Xpower = 1
## VOLT_C1_INDEX: VOLTAGE message specifies x variable
## and CONCEN1 variable specifies y variable of X_A and X_B tables;
## pg 323, sec 19.4.6 of Book of Genesis
self.Xindex = "VOLT_C1_INDEX"
## xGate was already created and wrapped when Xpower was set non-zero
#self.xGate = moose.HHGate2D(self.path + "/xGate")
#self.getContext().runG("showfield "+self.path +"/xGate/A -all")
self.xGate.A.xmin = VMIN
self.xGate.A.xmax = VMAX
#self.xGate.A.xdivs = NDIVS # these get overridden by the number of values in the table
self.xGate.B.xmin = VMIN
self.xGate.B.xmax = VMAX
#self.xGate.B.xdivs = NDIVS # these get overridden by the number of values in the table
### HHGate2D is not wrapped properly in pyMOOSE.
### ymin, ymax and ydivs are not exposed.
### Setting them creates new and useless attributes within HHGate2D without warning!
### Hence use runG to set these via Genesis command
self.getContext().runG("setfield "+self.path+"/xGate/A"+\
#" ydivs "+str(CaNDIVS)+\ # these get overridden by the number of values in the table
" ymin "+str(CaMIN)+\
" ymax "+str(CaMAX))
self.getContext().runG("setfield "+self.path+"/xGate/B"+\
#" ydivs "+str(CaNDIVS)+\ # these get overridden by the number of values in the table
" ymin "+str(CaMIN)+\
" ymax "+str(CaMAX))
selfdir = os.path.dirname(__file__)
if selfdir != '': selfdir += os.sep
ftableA = open(selfdir+"KCaA_PG.dat","w")
ftableB = open(selfdir+"KCaB_PG.dat","w")
v = VMIN
dCa = (CaMAX-CaMIN)/CaNDIVS
for i in range(NDIVS+1):
Ca = CaMIN
for j in range(CaNDIVS+1):
alpha = calc_KCa_PG_alpha_y(v,Ca)
ftableA.write(str(alpha)+" ")
ftableB.write(str(alpha+calc_KCa_PG_beta_y(v,Ca))+" ")
Ca += dCa
ftableA.write("\n")
ftableB.write("\n")
v += dv
ftableA.close()
ftableB.close()
### PRESENTLY, Interpol2D.cpp in MOOSE only allows loading via a data file,
### one cannot set individual entries A[0][0] etc.
### Thus pyMOOSE also has not wrapped Interpol2D
self.getContext().runG("call "+self.path+"/xGate/A load "+selfdir+"KCaA_PG.dat 0")
self.getContext().runG("call "+self.path+"/xGate/B load "+selfdir+"KCaB_PG.dat 0")
# Test print of table
#self.getContext().runG("call "+self.path+"/xGate/A print "+selfdir+"KCaA_out.dat")
#self.getContext().runG("call "+self.path+"/xGate/B print "+selfdir+"KCaB_out.dat")
# calc_mode is LIN_INTERP i.e. 1 by default, so no need to set it as below.
#self.getContext().runG("setfield "+self.path+" X_A->calc_mode 1")
#self.getContext().runG("setfield "+self.path+" X_B->calc_mode 1")