TITLE nax
: Na current for axon. No slow inact.
: M.Migliore Jul. 1997
: added sh to account for higher threshold M.Migliore, Apr.2002
NEURON {
SUFFIX Na_rat_ms : aditya changed name for granule cell
USEION na READ ena WRITE ina
RANGE gmax, sh : aditya replaced gbar with gmax
GLOBAL minf, hinf, mtau, htau,thinf, qinf
}
PARAMETER {
sh = 15 (mV) : aditya seet this for granule cell
gmax = 0.010 (mho/cm2)
tha = -30 (mV) : v 1/2 for act
qa = 7.2 (mV) : act slope (4.5)
Ra = 0.4 (/ms) : open (v)
Rb = 0.124 (/ms) : close (v)
thi1 = -45 (mV) : v 1/2 for inact
thi2 = -45 (mV) : v 1/2 for inact
qd = 1.5 (mV) : inact tau slope
qg = 1.5 (mV)
mmin=0.02
hmin=0.5
q10=2
Rg = 0.01 (/ms) : inact recov (v)
Rd = .03 (/ms) : inact (v)
thinf = -50 (mV) : inact inf slope
qinf = 4 (mV) : inact inf slope
ena (mV) : aditya - need 60mV for granule cell, but nrnivmodl won't allow ena to be set - it is set by the read in ena (see USEION above)
celsius : set this globally in Neuron
v (mV)
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(pS) = (picosiemens)
(um) = (micron)
}
ASSIGNED {
ina (mA/cm2)
thegna (mho/cm2)
minf hinf
mtau (ms) htau (ms)
}
STATE { m h}
BREAKPOINT {
SOLVE states METHOD cnexp
thegna = gmax*m*m*m*h
ina = thegna * (v - ena)
}
INITIAL {
ena = 60 (mV) : aditya set this for granule cell
trates(v,sh)
m=minf
h=hinf
}
DERIVATIVE states {
trates(v,sh)
m' = (minf-m)/mtau
h' = (hinf-h)/htau
}
PROCEDURE trates(vm,sh2) {
LOCAL a, b, qt
qt=q10^((celsius-24)/10)
a = trap0(vm,tha+sh2,Ra,qa)
b = trap0(-vm,-tha-sh2,Rb,qa)
mtau = 1/(a+b)/qt
if (mtau<mmin) {mtau=mmin}
minf = a/(a+b)
a = trap0(vm,thi1+sh2,Rd,qd)
b = trap0(-vm,-thi2-sh2,Rg,qg)
htau = 1/(a+b)/qt
if (htau<hmin) {htau=hmin}
hinf = 1/(1+exp((vm-thinf-sh2)/qinf))
}
FUNCTION trap0(v,th,a,q) {
if (fabs(v-th) > 1e-6) {
trap0 = a * (v - th) / (1 - exp(-(v - th)/q))
} else {
trap0 = a * q
}
}