COMMENT
Na channel from Schweighofer et al 1999.
The referred model is an inferior olive neuron
B. Torben-Nielsen @ HUJI, 21-10-2010
ENDCOMMENT
NEURON {
SUFFIX iona
USEION na READ ena WRITE ina
RANGE gbar,g,i,minf,hinf,tauh,m : now i can access these variables
}
UNITS {
(S) = (siemens)
(mS) = (millisiemens)
(mV) = (millivolt)
(mA) = (milliamp)
}
PARAMETER {
gbar = 70 (mS/cm2)
ena = 55 (mV)
}
ASSIGNED {
v (mV)
ina (mA/cm2)
i (mA/cm2)
g (mS/cm2)
minf
hinf
tauh (ms)
}
STATE {
h
}
INITIAL {
rates(v)
h = hinf
}
BREAKPOINT {
rates(v)
SOLVE states METHOD cnexp
g = gbar *minf*minf*minf*h
i = g * (v - ena)*(0.001)
ina = i
}
DERIVATIVE states {
h' = (hinf -h)/tauh
}
PROCEDURE rates(v (mV)) {
LOCAL a_h, b_h, a_m,b_m
UNITSOFF
if(fabs(v+41.0) < 1e-6) {
a_m=(0.1*(v+41.000001)) / ( 1-exp( -(v+41.000001)/10 ) )
} else {
a_m=(0.1*(v+41)) / ( 1-exp( -(v+41)/10 ) )
}
b_m=9.0*exp( -(v+66)/20 )
minf=a_m/(a_m+b_m)
a_h=5.0*exp( -(v+60)/15 )
b_h=(v+50) / ( 1-exp( -(v+50)/10 ) )
hinf=a_h/(a_h+b_h)
tauh=250/( a_h+b_h ) : was 170, 250
UNITSON
}