: simple first-order model of potassium dynamics
NEURON {
SUFFIX kdyn
USEION k READ ko,ik WRITE ko
RANGE ko, ki
}
UNITS {
(mM) = (milli/liter)
(mA) = (milliamp)
F = (faraday) (coul)
}
PARAMETER {
tk = 7 (ms) : decay time constant
koinf = 3.82 (mM) : equilibrium k+ concentration
kiinf = 140 (mM) :
dep = 70e-3 (micron) : depth of shell for k+ diffusion
KAF = 2 () : K accumulation factor
}
ASSIGNED {
ik (mA/cm2)
}
STATE { ko (mM) }
BREAKPOINT {
SOLVE states METHOD cnexp
}
DERIVATIVE states {
ko'= 1e4*KAF*ik/(F*dep) + (koinf-ko)/tk
}