/* Created by Language version: 7.5.0 */
/* NOT VECTORIZED */
#define NRN_VECTORIZED 0
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__cad
#define _nrn_initial _nrn_initial__cad
#define nrn_cur _nrn_cur__cad
#define _nrn_current _nrn_current__cad
#define nrn_jacob _nrn_jacob__cad
#define nrn_state _nrn_state__cad
#define _net_receive _net_receive__cad
#define state state__cad
#define _threadargscomma_ /**/
#define _threadargsprotocomma_ /**/
#define _threadargs_ /**/
#define _threadargsproto_ /**/
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define t nrn_threads->_t
#define dt nrn_threads->_dt
#define ca _p[0]
#define cai _p[1]
#define Dca _p[2]
#define ica _p[3]
#define drive_channel _p[4]
#define _g _p[5]
#define _ion_ica *_ppvar[0]._pval
#define _ion_cai *_ppvar[1]._pval
#define _style_ca *((int*)_ppvar[2]._pvoid)
#define diam *_ppvar[3]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
/* declaration of user functions */
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_p = _prop->param; _ppvar = _prop->dparam;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_cad", _hoc_setdata,
0, 0
};
/* declare global and static user variables */
#define cainf cainf_cad
double cainf = 0.0001;
#define depth depth_cad
double depth = 0.1;
#define gamma gamma_cad
double gamma = 1.2;
#define kb kb_cad
double kb = 20;
#define taur taur_cad
double taur = 15;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"depth_cad", "um",
"taur_cad", "ms",
"cainf_cad", "mM",
"gamma_cad", "1/ms",
"ca_cad", "mM",
0,0
};
static double ca0 = 0;
static double delta_t = 1;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"depth_cad", &depth_cad,
"taur_cad", &taur_cad,
"kb_cad", &kb_cad,
"cainf_cad", &cainf_cad,
"gamma_cad", &gamma_cad,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[4]._i
static void _ode_synonym(int, double**, Datum**);
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.5.0",
"cad",
0,
0,
"ca_cad",
0,
0};
static Symbol* _morphology_sym;
static Symbol* _ca_sym;
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 6, _prop);
/*initialize range parameters*/
_prop->param = _p;
_prop->param_size = 6;
_ppvar = nrn_prop_datum_alloc(_mechtype, 5, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_morphology_sym);
_ppvar[3]._pval = &prop_ion->param[0]; /* diam */
prop_ion = need_memb(_ca_sym);
nrn_check_conc_write(_prop, prop_ion, 1);
nrn_promote(prop_ion, 3, 0);
_ppvar[0]._pval = &prop_ion->param[3]; /* ica */
_ppvar[1]._pval = &prop_ion->param[1]; /* cai */
_ppvar[2]._pvoid = (void*)(&(prop_ion->dparam[0]._i)); /* iontype for ca */
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
"ca_cad", 1e-05,
0,0
};
static void _update_ion_pointer(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _Cad_reg() {
int _vectorized = 0;
_initlists();
ion_reg("ca", -10000.);
_morphology_sym = hoc_lookup("morphology");
_ca_sym = hoc_lookup("ca_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 0);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
hoc_register_prop_size(_mechtype, 6, 5);
hoc_register_dparam_semantics(_mechtype, 0, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 1, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 2, "#ca_ion");
hoc_register_dparam_semantics(_mechtype, 4, "cvodeieq");
hoc_register_dparam_semantics(_mechtype, 3, "diam");
nrn_writes_conc(_mechtype, 0);
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_synonym(_mechtype, _ode_synonym);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 cad /Users/Penny/Dropbox/ModelDB/mod/x86_64/Cad.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static double FARADAY = 96485.3;
static int _reset;
static char *modelname = "decay of internal calcium concentration";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static double *_temp1;
static int _slist1[1], _dlist1[1];
static int state(_threadargsproto_);
/*CVODE*/
static int _ode_spec1 () {_reset=0;
{
depth = diam / 4.0 ;
drive_channel = - ( 10000.0 ) * ica / ( 2.0 * FARADAY * depth ) ;
if ( drive_channel <= 0. ) {
drive_channel = 0. ;
}
taur = kb / gamma ;
Dca = ( drive_channel / kb ) + ( ( cainf - ca ) / taur ) ;
cai = ca ;
}
return _reset;
}
static int _ode_matsol1 () {
depth = diam / 4.0 ;
drive_channel = - ( 10000.0 ) * ica / ( 2.0 * FARADAY * depth ) ;
if ( drive_channel <= 0. ) {
drive_channel = 0. ;
}
taur = kb / gamma ;
Dca = Dca / (1. - dt*( ( ( ( ( - 1.0 ) ) ) / taur ) )) ;
cai = ca ;
return 0;
}
/*END CVODE*/
static int state () {_reset=0;
{
depth = diam / 4.0 ;
drive_channel = - ( 10000.0 ) * ica / ( 2.0 * FARADAY * depth ) ;
if ( drive_channel <= 0. ) {
drive_channel = 0. ;
}
taur = kb / gamma ;
Dca = ( drive_channel / kb ) + ( ( cainf - ca ) / taur ) ;
cai = ca ;
}
return _reset;}
static int _ode_count(int _type){ return 1;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ica = _ion_ica;
cai = _ion_cai;
cai = _ion_cai;
_ode_spec1 ();
_ion_cai = cai;
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 1; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_synonym(int _cnt, double** _pp, Datum** _ppd) {
int _i;
for (_i=0; _i < _cnt; ++_i) {_p = _pp[_i]; _ppvar = _ppd[_i];
_ion_cai = ca ;
}}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 ();
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ica = _ion_ica;
cai = _ion_cai;
cai = _ion_cai;
_ode_matsol_instance1(_threadargs_);
}}
extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
static void _update_ion_pointer(Datum* _ppvar) {
nrn_update_ion_pointer(_ca_sym, _ppvar, 0, 3);
nrn_update_ion_pointer(_ca_sym, _ppvar, 1, 1);
}
static void initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
ca = ca0;
{
ca = cainf ;
cai = ca ;
}
_sav_indep = t; t = _save;
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
ica = _ion_ica;
cai = _ion_cai;
cai = _ion_cai;
initmodel();
_ion_cai = cai;
nrn_wrote_conc(_ca_sym, (&(_ion_cai)) - 1, _style_ca);
}}
static double _nrn_current(double _v){double _current=0.;v=_v;{
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
}}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
double _dtsav = dt;
if (secondorder) { dt *= 0.5; }
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
ica = _ion_ica;
cai = _ion_cai;
cai = _ion_cai;
{ error = euler(_ninits, 1, _slist1, _dlist1, _p, &t, dt, state, &_temp1);
if(error){fprintf(stderr,"at line 67 in file Cad.mod:\n SOLVE state METHOD euler\n"); nrn_complain(_p); abort_run(error);}
if (secondorder) {
int _i;
for (_i = 0; _i < 1; ++_i) {
_p[_slist1[_i]] += dt*_p[_dlist1[_i]];
}}
} {
}
_ion_cai = cai;
}}
dt = _dtsav;
}
static void terminal(){}
static void _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(ca) - _p; _dlist1[0] = &(Dca) - _p;
_first = 0;
}