/* Created by Language version: 7.5.0 */
/* VECTORIZED */
#define NRN_VECTORIZED 1
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__NMDAeee
#define _nrn_initial _nrn_initial__NMDAeee
#define nrn_cur _nrn_cur__NMDAeee
#define _nrn_current _nrn_current__NMDAeee
#define nrn_jacob _nrn_jacob__NMDAeee
#define nrn_state _nrn_state__NMDAeee
#define _net_receive _net_receive__NMDAeee
#define release release__NMDAeee
#define _threadargscomma_ _p, _ppvar, _thread, _nt,
#define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt,
#define _threadargs_ _p, _ppvar, _thread, _nt
#define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
/* Thread safe. No static _p or _ppvar. */
#define t _nt->_t
#define dt _nt->_dt
#define Cdur _p[0]
#define Alpha _p[1]
#define Beta _p[2]
#define e _p[3]
#define gmax _p[4]
#define iNMDA _p[5]
#define g _p[6]
#define ica _p[7]
#define Ron _p[8]
#define Roff _p[9]
#define Rinf _p[10]
#define Rtau _p[11]
#define synon _p[12]
#define B _p[13]
#define cai _p[14]
#define cao _p[15]
#define DRon _p[16]
#define DRoff _p[17]
#define v _p[18]
#define _g _p[19]
#define _tsav _p[20]
#define _nd_area *_ppvar[0]._pval
#define _ion_cai *_ppvar[2]._pval
#define _ion_cao *_ppvar[3]._pval
#define _ion_ica *_ppvar[4]._pval
#define _ion_dicadv *_ppvar[5]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
static Datum* _extcall_thread;
static Prop* _extcall_prop;
/* external NEURON variables */
extern double celsius;
/* declaration of user functions */
static double _hoc_ghk();
static double _hoc_ghkg();
static double _hoc_mgblock();
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
extern Prop* nrn_point_prop_;
static int _pointtype;
static void* _hoc_create_pnt(_ho) Object* _ho; { void* create_point_process();
return create_point_process(_pointtype, _ho);
}
static void _hoc_destroy_pnt();
static double _hoc_loc_pnt(_vptr) void* _vptr; {double loc_point_process();
return loc_point_process(_pointtype, _vptr);
}
static double _hoc_has_loc(_vptr) void* _vptr; {double has_loc_point();
return has_loc_point(_vptr);
}
static double _hoc_get_loc_pnt(_vptr)void* _vptr; {
double get_loc_point_process(); return (get_loc_point_process(_vptr));
}
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_extcall_prop = _prop;
}
static void _hoc_setdata(void* _vptr) { Prop* _prop;
_prop = ((Point_process*)_vptr)->_prop;
_setdata(_prop);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
0,0
};
static Member_func _member_func[] = {
"loc", _hoc_loc_pnt,
"has_loc", _hoc_has_loc,
"get_loc", _hoc_get_loc_pnt,
"ghk", _hoc_ghk,
"ghkg", _hoc_ghkg,
"mgblock", _hoc_mgblock,
0, 0
};
#define _f_mgblock _f_mgblock_NMDAeee
#define ghk ghk_NMDAeee
#define ghkg ghkg_NMDAeee
#define mgblock mgblock_NMDAeee
extern double _f_mgblock( _threadargsprotocomma_ double );
extern double ghk( _threadargsprotocomma_ double , double , double , double );
extern double ghkg( _threadargsprotocomma_ double , double , double , double );
extern double mgblock( _threadargsprotocomma_ double );
static void _check_mgblock(double*, Datum*, Datum*, _NrnThread*);
static void _check_table_thread(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, int _type) {
_check_mgblock(_p, _ppvar, _thread, _nt);
}
/* declare global and static user variables */
#define Cmax Cmax_NMDAeee
double Cmax = 1;
#define fracca fracca_NMDAeee
double fracca = 0.13;
#define mg mg_NMDAeee
double mg = 1;
#define usetable usetable_NMDAeee
double usetable = 1;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
"usetable_NMDAeee", 0, 1,
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"Cmax_NMDAeee", "mM",
"mg_NMDAeee", "mM",
"Cdur", "ms",
"Alpha", "/ms",
"Beta", "/ms",
"e", "mV",
"gmax", "uS",
"iNMDA", "nA",
"g", "umho",
0,0
};
static double Roff0 = 0;
static double Ron0 = 0;
static double delta_t = 0.01;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"Cmax_NMDAeee", &Cmax_NMDAeee,
"mg_NMDAeee", &mg_NMDAeee,
"fracca_NMDAeee", &fracca_NMDAeee,
"usetable_NMDAeee", &usetable_NMDAeee,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static void _hoc_destroy_pnt(_vptr) void* _vptr; {
destroy_point_process(_vptr);
}
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[7]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.5.0",
"NMDAeee",
"Cdur",
"Alpha",
"Beta",
"e",
"gmax",
0,
"iNMDA",
"g",
"ica",
0,
"Ron",
"Roff",
0,
0};
static Symbol* _ca_sym;
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
if (nrn_point_prop_) {
_prop->_alloc_seq = nrn_point_prop_->_alloc_seq;
_p = nrn_point_prop_->param;
_ppvar = nrn_point_prop_->dparam;
}else{
_p = nrn_prop_data_alloc(_mechtype, 21, _prop);
/*initialize range parameters*/
Cdur = 1;
Alpha = 4;
Beta = 0.0015;
e = 0;
gmax = 1;
}
_prop->param = _p;
_prop->param_size = 21;
if (!nrn_point_prop_) {
_ppvar = nrn_prop_datum_alloc(_mechtype, 8, _prop);
}
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_ca_sym);
nrn_promote(prop_ion, 1, 0);
_ppvar[2]._pval = &prop_ion->param[1]; /* cai */
_ppvar[3]._pval = &prop_ion->param[2]; /* cao */
_ppvar[4]._pval = &prop_ion->param[3]; /* ica */
_ppvar[5]._pval = &prop_ion->param[4]; /* _ion_dicadv */
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
#define _tqitem &(_ppvar[6]._pvoid)
static void _net_receive(Point_process*, double*, double);
static void _update_ion_pointer(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _NMDAeee_reg() {
int _vectorized = 1;
_initlists();
ion_reg("ca", -10000.);
_ca_sym = hoc_lookup("ca_ion");
_pointtype = point_register_mech(_mechanism,
nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init,
hoc_nrnpointerindex, 1,
_hoc_create_pnt, _hoc_destroy_pnt, _member_func);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
_nrn_thread_table_reg(_mechtype, _check_table_thread);
hoc_register_prop_size(_mechtype, 21, 8);
hoc_register_dparam_semantics(_mechtype, 0, "area");
hoc_register_dparam_semantics(_mechtype, 1, "pntproc");
hoc_register_dparam_semantics(_mechtype, 2, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 3, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 4, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 5, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 6, "netsend");
hoc_register_dparam_semantics(_mechtype, 7, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
pnt_receive[_mechtype] = _net_receive;
pnt_receive_size[_mechtype] = 5;
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 NMDAeee /Users/Penny/Dropbox/ModelDB/mod/x86_64/NMDAeee.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static double FARADAY = 96485.3;
static double R = 8.3145;
static double *_t_mgblock;
static int _reset;
static char *modelname = "simple NMDA receptors";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static double _n_mgblock(_threadargsprotocomma_ double _lv);
static int _slist1[2], _dlist1[2];
static int release(_threadargsproto_);
double ghkg ( _threadargsprotocomma_ double _lv , double _lci , double _lco , double _lz ) {
double _lghkg;
double _lxi , _lf , _lexi , _lfxi ;
_lf = R * ( celsius + 273.15 ) / ( _lz * ( 1e-3 ) * FARADAY ) ;
_lxi = _lv / _lf ;
_lexi = exp ( _lxi ) ;
if ( fabs ( _lxi ) < 1e-4 ) {
_lfxi = 1.0 - _lxi / 2.0 ;
}
else {
_lfxi = _lxi / ( _lexi - 1.0 ) ;
}
_lghkg = _lf * ( ( _lci / _lco ) * _lexi - 1.0 ) * _lfxi ;
return _lghkg;
}
static double _hoc_ghkg(void* _vptr) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
_p = ((Point_process*)_vptr)->_prop->param;
_ppvar = ((Point_process*)_vptr)->_prop->dparam;
_thread = _extcall_thread;
_nt = (_NrnThread*)((Point_process*)_vptr)->_vnt;
_r = ghkg ( _p, _ppvar, _thread, _nt, *getarg(1) , *getarg(2) , *getarg(3) , *getarg(4) );
return(_r);
}
double ghk ( _threadargsprotocomma_ double _lv , double _lci , double _lco , double _lz ) {
double _lghk;
double _lxi , _lf , _lexi , _lfxi ;
_lf = R * ( celsius + 273.15 ) / ( _lz * ( 1e-3 ) * FARADAY ) ;
_lxi = _lv / _lf ;
_lexi = exp ( _lxi ) ;
if ( fabs ( _lxi ) < 1e-4 ) {
_lfxi = 1.0 - _lxi / 2.0 ;
}
else {
_lfxi = _lxi / ( _lexi - 1.0 ) ;
}
_lghk = ( .001 ) * _lz * FARADAY * ( _lci * _lexi - _lco ) * _lfxi ;
return _lghk;
}
static double _hoc_ghk(void* _vptr) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
_p = ((Point_process*)_vptr)->_prop->param;
_ppvar = ((Point_process*)_vptr)->_prop->dparam;
_thread = _extcall_thread;
_nt = (_NrnThread*)((Point_process*)_vptr)->_vnt;
_r = ghk ( _p, _ppvar, _thread, _nt, *getarg(1) , *getarg(2) , *getarg(3) , *getarg(4) );
return(_r);
}
/*CVODE*/
static int _ode_spec1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {int _reset = 0; {
DRon = ( synon * Rinf - Ron ) / Rtau ;
DRoff = - Beta * Roff ;
}
return _reset;
}
static int _ode_matsol1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
DRon = DRon / (1. - dt*( ( ( ( - 1.0 ) ) ) / Rtau )) ;
DRoff = DRoff / (1. - dt*( ( - Beta )*( 1.0 ) )) ;
return 0;
}
/*END CVODE*/
static int release (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) { {
Ron = Ron + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / Rtau)))*(- ( ( ( ( synon )*( Rinf ) ) ) / Rtau ) / ( ( ( ( - 1.0 ) ) ) / Rtau ) - Ron) ;
Roff = Roff + (1. - exp(dt*(( - Beta )*( 1.0 ))))*(- ( 0.0 ) / ( ( - Beta )*( 1.0 ) ) - Roff) ;
}
return 0;
}
static double _mfac_mgblock, _tmin_mgblock;
static void _check_mgblock(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
static int _maktable=1; int _i, _j, _ix = 0;
double _xi, _tmax;
static double _sav_mg;
if (!usetable) {return;}
if (_sav_mg != mg) { _maktable = 1;}
if (_maktable) { double _x, _dx; _maktable=0;
_tmin_mgblock = - 140.0 ;
_tmax = 80.0 ;
_dx = (_tmax - _tmin_mgblock)/1000.; _mfac_mgblock = 1./_dx;
for (_i=0, _x=_tmin_mgblock; _i < 1001; _x += _dx, _i++) {
_t_mgblock[_i] = _f_mgblock(_p, _ppvar, _thread, _nt, _x);
}
_sav_mg = mg;
}
}
double mgblock(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, double _lv) {
#if 0
_check_mgblock(_p, _ppvar, _thread, _nt);
#endif
return _n_mgblock(_p, _ppvar, _thread, _nt, _lv);
}
static double _n_mgblock(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, double _lv){ int _i, _j;
double _xi, _theta;
if (!usetable) {
return _f_mgblock(_p, _ppvar, _thread, _nt, _lv);
}
_xi = _mfac_mgblock * (_lv - _tmin_mgblock);
if (isnan(_xi)) {
return _xi; }
if (_xi <= 0.) {
return _t_mgblock[0];
}
if (_xi >= 1000.) {
return _t_mgblock[1000];
}
_i = (int) _xi;
return _t_mgblock[_i] + (_xi - (double)_i)*(_t_mgblock[_i+1] - _t_mgblock[_i]);
}
double _f_mgblock ( _threadargsprotocomma_ double _lv ) {
double _lmgblock;
_lmgblock = 1.0 / ( 1.0 + exp ( 0.062 * - _lv ) * ( mg / 3.57 ) ) ;
return _lmgblock;
}
static double _hoc_mgblock(void* _vptr) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
_p = ((Point_process*)_vptr)->_prop->param;
_ppvar = ((Point_process*)_vptr)->_prop->dparam;
_thread = _extcall_thread;
_nt = (_NrnThread*)((Point_process*)_vptr)->_vnt;
#if 1
_check_mgblock(_p, _ppvar, _thread, _nt);
#endif
_r = mgblock ( _p, _ppvar, _thread, _nt, *getarg(1) );
return(_r);
}
static void _net_receive (_pnt, _args, _lflag) Point_process* _pnt; double* _args; double _lflag;
{ double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
_thread = (Datum*)0; _nt = (_NrnThread*)_pnt->_vnt; _p = _pnt->_prop->param; _ppvar = _pnt->_prop->dparam;
if (_tsav > t){ extern char* hoc_object_name(); hoc_execerror(hoc_object_name(_pnt->ob), ":Event arrived out of order. Must call ParallelContext.set_maxstep AFTER assigning minimum NetCon.delay");}
_tsav = t; if (_lflag == 1. ) {*(_tqitem) = 0;}
{
if ( _lflag == 0.0 ) {
_args[2] = _args[2] + 1.0 ;
if ( ! _args[1] ) {
_args[3] = _args[3] * exp ( - Beta * ( t - _args[4] ) ) ;
_args[4] = t ;
_args[1] = 1.0 ;
synon = synon + _args[0] ;
if (nrn_netrec_state_adjust && !cvode_active_){
/* discon state adjustment for cnexp case (rate uses no local variable) */
double __state = Ron;
double __primary = (Ron + _args[3] ) - __state;
__primary += ( 1. - exp( 0.5*dt*( ( ( ( - 1.0 ) ) ) / Rtau ) ) )*( - ( ( ( ( synon )*( Rinf ) ) ) / Rtau ) / ( ( ( ( - 1.0 ) ) ) / Rtau ) - __primary );
Ron += __primary;
} else {
Ron = Ron + _args[3] ;
}
if (nrn_netrec_state_adjust && !cvode_active_){
/* discon state adjustment for cnexp case (rate uses no local variable) */
double __state = Roff;
double __primary = (Roff - _args[3] ) - __state;
__primary += ( 1. - exp( 0.5*dt*( ( - Beta )*( 1.0 ) ) ) )*( - ( 0.0 ) / ( ( - Beta )*( 1.0 ) ) - __primary );
Roff += __primary;
} else {
Roff = Roff - _args[3] ;
}
}
net_send ( _tqitem, _args, _pnt, t + Cdur , _args[2] ) ;
}
if ( _lflag == _args[2] ) {
_args[3] = _args[0] * Rinf + ( _args[3] - _args[0] * Rinf ) * exp ( - ( t - _args[4] ) / Rtau ) ;
_args[4] = t ;
synon = synon - _args[0] ;
if (nrn_netrec_state_adjust && !cvode_active_){
/* discon state adjustment for cnexp case (rate uses no local variable) */
double __state = Ron;
double __primary = (Ron - _args[3] ) - __state;
__primary += ( 1. - exp( 0.5*dt*( ( ( ( - 1.0 ) ) ) / Rtau ) ) )*( - ( ( ( ( synon )*( Rinf ) ) ) / Rtau ) / ( ( ( ( - 1.0 ) ) ) / Rtau ) - __primary );
Ron += __primary;
} else {
Ron = Ron - _args[3] ;
}
if (nrn_netrec_state_adjust && !cvode_active_){
/* discon state adjustment for cnexp case (rate uses no local variable) */
double __state = Roff;
double __primary = (Roff + _args[3] ) - __state;
__primary += ( 1. - exp( 0.5*dt*( ( - Beta )*( 1.0 ) ) ) )*( - ( 0.0 ) / ( ( - Beta )*( 1.0 ) ) - __primary );
Roff += __primary;
} else {
Roff = Roff + _args[3] ;
}
_args[1] = 0.0 ;
}
} }
static int _ode_count(int _type){ return 2;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
cai = _ion_cai;
cao = _ion_cao;
_ode_spec1 (_p, _ppvar, _thread, _nt);
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
double* _p; Datum* _ppvar;
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 2; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 (_p, _ppvar, _thread, _nt);
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
cai = _ion_cai;
cao = _ion_cao;
_ode_matsol_instance1(_threadargs_);
}}
extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
static void _update_ion_pointer(Datum* _ppvar) {
nrn_update_ion_pointer(_ca_sym, _ppvar, 2, 1);
nrn_update_ion_pointer(_ca_sym, _ppvar, 3, 2);
nrn_update_ion_pointer(_ca_sym, _ppvar, 4, 3);
nrn_update_ion_pointer(_ca_sym, _ppvar, 5, 4);
}
static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
int _i; double _save;{
Roff = Roff0;
Ron = Ron0;
{
Rinf = Cmax * Alpha / ( Cmax * Alpha + Beta ) ;
Rtau = 1.0 / ( Cmax * Alpha + Beta ) ;
synon = 0.0 ;
}
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if 0
_check_mgblock(_p, _ppvar, _thread, _nt);
#endif
_tsav = -1e20;
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
cai = _ion_cai;
cao = _ion_cao;
initmodel(_p, _ppvar, _thread, _nt);
}
}
static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, double _v){double _current=0.;v=_v;{ {
B = mgblock ( _threadargscomma_ v ) ;
g = ( Ron + Roff ) * B * gmax ;
iNMDA = g * ( v - e ) * ( 1.0 - fracca ) ;
if ( fracca > 0.0 ) {
ica = g * ghkg ( _threadargscomma_ v , cai , cao , 2.0 ) * fracca ;
}
}
_current += ica;
_current += iNMDA;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
cai = _ion_cai;
cao = _ion_cao;
_g = _nrn_current(_p, _ppvar, _thread, _nt, _v + .001);
{ double _dica;
_dica = ica;
_rhs = _nrn_current(_p, _ppvar, _thread, _nt, _v);
_ion_dicadv += (_dica - ica)/.001 * 1.e2/ (_nd_area);
}
_g = (_g - _rhs)/.001;
_ion_ica += ica * 1.e2/ (_nd_area);
_g *= 1.e2/(_nd_area);
_rhs *= 1.e2/(_nd_area);
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}
}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}
}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
cai = _ion_cai;
cao = _ion_cao;
{ release(_p, _ppvar, _thread, _nt);
} }}
}
static void terminal(){}
static void _initlists(){
double _x; double* _p = &_x;
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(Ron) - _p; _dlist1[0] = &(DRon) - _p;
_slist1[1] = &(Roff) - _p; _dlist1[1] = &(DRoff) - _p;
_t_mgblock = makevector(1001*sizeof(double));
_first = 0;
}
#if defined(__cplusplus)
} /* extern "C" */
#endif