/* Created by Language version: 7.5.0 */
/* VECTORIZED */
#define NRN_VECTORIZED 1
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__hd
#define _nrn_initial _nrn_initial__hd
#define nrn_cur _nrn_cur__hd
#define _nrn_current _nrn_current__hd
#define nrn_jacob _nrn_jacob__hd
#define nrn_state _nrn_state__hd
#define _net_receive _net_receive__hd
#define rate rate__hd
#define states states__hd
#define _threadargscomma_ _p, _ppvar, _thread, _nt,
#define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt,
#define _threadargs_ _p, _ppvar, _thread, _nt
#define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
/* Thread safe. No static _p or _ppvar. */
#define t _nt->_t
#define dt _nt->_dt
#define gbar _p[0]
#define vhalfl _p[1]
#define clk _p[2]
#define elk _p[3]
#define i _p[4]
#define lk _p[5]
#define glk _p[6]
#define l _p[7]
#define Dl _p[8]
#define ghd _p[9]
#define v _p[10]
#define _g _p[11]
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
static Datum* _extcall_thread;
static Prop* _extcall_prop;
/* external NEURON variables */
extern double celsius;
/* declaration of user functions */
static void _hoc_alpt(void);
static void _hoc_alpl(void);
static void _hoc_bett(void);
static void _hoc_rate(void);
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_extcall_prop = _prop;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_hd", _hoc_setdata,
"alpt_hd", _hoc_alpt,
"alpl_hd", _hoc_alpl,
"bett_hd", _hoc_bett,
"rate_hd", _hoc_rate,
0, 0
};
#define alpt alpt_hd
#define alpl alpl_hd
#define bett bett_hd
extern double alpt( _threadargsprotocomma_ double );
extern double alpl( _threadargsprotocomma_ double );
extern double bett( _threadargsprotocomma_ double );
/* declare global and static user variables */
static int _thread1data_inuse = 0;
static double _thread1data[2];
#define _gth 0
#define a0t a0t_hd
double a0t = 0.0046;
#define ehd ehd_hd
double ehd = -30;
#define gmt gmt_hd
double gmt = 0.4;
#define linf_hd _thread1data[0]
#define linf _thread[_gth]._pval[0]
#define qtl qtl_hd
double qtl = 1;
#define q10 q10_hd
double q10 = 4.5;
#define taul_hd _thread1data[1]
#define taul _thread[_gth]._pval[1]
#define vhalft vhalft_hd
double vhalft = -75;
#define zetat zetat_hd
double zetat = 2.2;
#define zetal zetal_hd
double zetal = 4;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"ehd_hd", "mV",
"vhalft_hd", "mV",
"a0t_hd", "/ms",
"zetal_hd", "1",
"zetat_hd", "1",
"gmt_hd", "1",
"gbar_hd", "mho/cm2",
"vhalfl_hd", "mV",
"elk_hd", "mV",
"i_hd", "mA/cm2",
"lk_hd", "mA/cm2",
0,0
};
static double delta_t = 0.01;
static double l0 = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"ehd_hd", &ehd_hd,
"vhalft_hd", &vhalft_hd,
"a0t_hd", &a0t_hd,
"zetal_hd", &zetal_hd,
"zetat_hd", &zetat_hd,
"gmt_hd", &gmt_hd,
"q10_hd", &q10_hd,
"qtl_hd", &qtl_hd,
"linf_hd", &linf_hd,
"taul_hd", &taul_hd,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[0]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.5.0",
"hd",
"gbar_hd",
"vhalfl_hd",
"clk_hd",
"elk_hd",
0,
"i_hd",
"lk_hd",
"glk_hd",
0,
"l_hd",
0,
0};
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 12, _prop);
/*initialize range parameters*/
gbar = 0.0001;
vhalfl = -90;
clk = 0;
elk = -70;
_prop->param = _p;
_prop->param_size = 12;
_ppvar = nrn_prop_datum_alloc(_mechtype, 1, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
static void _thread_mem_init(Datum*);
static void _thread_cleanup(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _h_migliore_reg() {
int _vectorized = 1;
_initlists();
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 2);
_extcall_thread = (Datum*)ecalloc(1, sizeof(Datum));
_thread_mem_init(_extcall_thread);
_thread1data_inuse = 0;
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 1, _thread_mem_init);
_nrn_thread_reg(_mechtype, 0, _thread_cleanup);
hoc_register_prop_size(_mechtype, 12, 1);
hoc_register_dparam_semantics(_mechtype, 0, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 hd /Users/Penny/Dropbox/ModelDB/mod/x86_64/h_migliore.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "I-h channel from Magee 1998 for distal dendrites";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rate(_threadargsprotocomma_ double);
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[1], _dlist1[1];
static int states(_threadargsproto_);
double alpl ( _threadargsprotocomma_ double _lv ) {
double _lalpl;
_lalpl = exp ( 0.0378 * zetal * ( _lv - vhalfl ) ) ;
return _lalpl;
}
static void _hoc_alpl(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = alpl ( _p, _ppvar, _thread, _nt, *getarg(1) );
hoc_retpushx(_r);
}
double alpt ( _threadargsprotocomma_ double _lv ) {
double _lalpt;
_lalpt = exp ( 0.0378 * zetat * ( _lv - vhalft ) ) ;
return _lalpt;
}
static void _hoc_alpt(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = alpt ( _p, _ppvar, _thread, _nt, *getarg(1) );
hoc_retpushx(_r);
}
double bett ( _threadargsprotocomma_ double _lv ) {
double _lbett;
_lbett = exp ( 0.0378 * zetat * gmt * ( _lv - vhalft ) ) ;
return _lbett;
}
static void _hoc_bett(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = bett ( _p, _ppvar, _thread, _nt, *getarg(1) );
hoc_retpushx(_r);
}
/*CVODE*/
static int _ode_spec1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {int _reset = 0; {
rate ( _threadargscomma_ v ) ;
Dl = ( linf - l ) / taul ;
}
return _reset;
}
static int _ode_matsol1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
rate ( _threadargscomma_ v ) ;
Dl = Dl / (1. - dt*( ( ( ( - 1.0 ) ) ) / taul )) ;
return 0;
}
/*END CVODE*/
static int states (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) { {
rate ( _threadargscomma_ v ) ;
l = l + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / taul)))*(- ( ( ( linf ) ) / taul ) / ( ( ( ( - 1.0 ) ) ) / taul ) - l) ;
}
return 0;
}
static int rate ( _threadargsprotocomma_ double _lv ) {
double _la , _lqt ;
_lqt = pow( q10 , ( ( celsius - 33.0 ) / 10.0 ) ) ;
_la = alpt ( _threadargscomma_ _lv ) ;
linf = 1.0 / ( 1.0 + alpl ( _threadargscomma_ _lv ) ) ;
taul = bett ( _threadargscomma_ _lv ) / ( qtl * _lqt * a0t * ( 1.0 + _la ) ) ;
return 0; }
static void _hoc_rate(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = 1.;
rate ( _p, _ppvar, _thread, _nt, *getarg(1) );
hoc_retpushx(_r);
}
static int _ode_count(int _type){ return 1;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_spec1 (_p, _ppvar, _thread, _nt);
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
double* _p; Datum* _ppvar;
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 1; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 (_p, _ppvar, _thread, _nt);
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_matsol_instance1(_threadargs_);
}}
static void _thread_mem_init(Datum* _thread) {
if (_thread1data_inuse) {_thread[_gth]._pval = (double*)ecalloc(2, sizeof(double));
}else{
_thread[_gth]._pval = _thread1data; _thread1data_inuse = 1;
}
}
static void _thread_cleanup(Datum* _thread) {
if (_thread[_gth]._pval == _thread1data) {
_thread1data_inuse = 0;
}else{
free((void*)_thread[_gth]._pval);
}
}
static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
int _i; double _save;{
l = l0;
{
rate ( _threadargscomma_ v ) ;
l = linf ;
}
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
initmodel(_p, _ppvar, _thread, _nt);
}
}
static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, double _v){double _current=0.;v=_v;{ {
ghd = gbar * l ;
i = ghd * ( v - ehd ) ;
lk = clk * gbar * ( v - elk ) ;
}
_current += i;
_current += lk;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_g = _nrn_current(_p, _ppvar, _thread, _nt, _v + .001);
{ _rhs = _nrn_current(_p, _ppvar, _thread, _nt, _v);
}
_g = (_g - _rhs)/.001;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}
}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}
}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
{ states(_p, _ppvar, _thread, _nt);
}}}
}
static void terminal(){}
static void _initlists(){
double _x; double* _p = &_x;
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(l) - _p; _dlist1[0] = &(Dl) - _p;
_first = 0;
}
#if defined(__cplusplus)
} /* extern "C" */
#endif