% iKDR: fast, delayed rectifier potassium current (ref: Kramer/Kopell 2008) % Tags: sodium, channel, intrinsic %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % Parameters % RS=excitatory (Regular Spiking); from [1] % IN=inhibitory; from [2] gKDR=20 % 20 for RS/IN KDR_V1=29.5 % 29.5 RS, 27 IN KDR_d1 = 10; % 10 RS, 11.5 IN KDR_V2 = 10; % 10 RS, 10 IN KDR_d2 = 10; % 10 RS, 10 IN E_KDR = -95; % -95 RS, -100 IN IC=0; IC_noise=0 % Functions minf(X) = 1./(1+exp((-X-KDR_V1)/KDR_d1)) % [Traub, 2003] mtau(X) = .25+4.35*exp(-abs(X+KDR_V2)/KDR_d2) % [Traub, 2003] aM(X) = minf(X) ./ mtau(X) bM(X) = (1-minf(X))./mtau(X) IKDR(X,m) = gKDR.*m.^4.*(X-E_KDR) % ODEs mKDR' = aM(X).*(1-mKDR)-bM(X).*mKDR mKDR(0)=IC+IC_noise.*rand(Npop,1) % Interface @current += -IKDR(X,mKDR) %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % References: % Kramer, M. A., Roopun, A. K., Carracedo, L. M., Traub, R. D., Whittington, M. A., & Kopell, N. J. (2008). Rhythm generation through period concatenation in rat somatosensory cortex. PLoS computational biology, 4(9), e1000169. (http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000169) % Based on: % [1] Traub RD, Buhl EH, Gloveli T, Whittington MA (2003) Fast rhythmic bursting can be induced in layer 2/3 cortical neurons by enhancing persistent Na+ conductance or by blocking BK channels. J Neurophysiol 89:909–921. % [2] Cunningham MO, Whittington MA, Bibbig A, Roopun A, LeBeau FEN, et al. (2004) A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro. Proc Natl Acad Sci USA 101:7152–7157.