begintemplate MRGMyelAxon
public init, create_sections, topol, subsets, geom, biophys
public NODE, MYSA, FLUT, STIN
public all
// Start initializing the class
proc init() {
create_sections($o1)
topol($o1)
biophys($o1)
}
// Create sections
create NODE[1], MYSA[1], FLUT[1], STIN[1]
proc create_sections() {
n_rn = $o1.get("section_counter").get("node")
n_mysa = $o1.get("section_counter").get("MYSA")
n_flut = $o1.get("section_counter").get("FLUT")
n_stin = $o1.get("section_counter").get("STIN")
create NODE[n_rn], MYSA[n_mysa], FLUT[n_flut], STIN[n_stin]
}
// Subsets, topology, geometry and biophysics
objref all, sctps, sec, next_sec
proc topol() { local i, i_rn, i_mysa, i_flut, i_stin
objref all, sec, next_sec
all = new SectionList()
n_rn = $o1.get("section_counter").get("node")
n_mysa = $o1.get("section_counter").get("MYSA")
n_flut = $o1.get("section_counter").get("FLUT")
n_stin = $o1.get("section_counter").get("STIN")
n_mx = $o1.get("mx_n")
nsecs = $o1.get("nsecs")
sctps = $o1.get("sectypes")
i_rn = 0
i_mysa = 0
i_flut = 0
i_stin = 0
for i=0, nsecs-1 {
// Select the section
sec = sctps.o(i)
// Connect NODE to MYSA
if (strcmp(sec.sectype, "node") == 0) {
if (i_rn < n_rn-1) {
NODE[i_rn] connect MYSA[i_mysa](0), 1
}
if (i_rn == n_rn-1) {
if (i < nsecs-1) {
NODE[i_rn] connect MYSA[i_mysa](0), 1
}
}
NODE[i_rn] all.append()
i_rn += 1
}
// MYSA and FLUT
// MYSA
if (strcmp(sec.sectype, "MYSA") == 0) {
if (i < nsecs-1){
// Connect
// This can go with NODE or with FLUT
next_sec = sctps.o(i+1)
// Connect MYSA to FLUT
if (strcmp(next_sec.sectype, "FLUT") == 0) {
MYSA[i_mysa] connect FLUT[i_flut](0), 1
}
// Connect MYSA to NODE
if (strcmp(next_sec.sectype, "node") == 0) {
MYSA[i_mysa] connect NODE[i_rn](0), 1
}
}
MYSA[i_mysa] all.append()
i_mysa += 1
}
// FLUT
if (strcmp(sec.sectype, "FLUT") == 0) {
if (i < nsecs-1){
// Connect
// This can go with STIN or with MYSA
next_sec = sctps.o(i+1)
// Connect FLUT to STIN
if (strcmp(next_sec.sectype, "STIN") == 0) {
FLUT[i_flut] connect STIN[i_stin](0), 1
}
// Connect FLUT to MYSA
if (strcmp(next_sec.sectype, "MYSA") == 0) {
FLUT[i_flut] connect MYSA[i_mysa](0), 1
}
}
FLUT[i_flut] all.append()
i_flut += 1
}
// Connect STIN to FLUT
if (strcmp(sec.sectype, "STIN") == 0) {
if (i_stin < n_stin-1) {
STIN[i_stin] connect FLUT[i_flut](0), 1
}
if (i_stin == n_stin-1) {
if (i < nsecs-1) {
STIN[i_stin] connect FLUT[i_flut](0), 1
}
}
STIN[i_stin] all.append()
i_stin += 1
}
}
}
objref l_rn, l_mysa, l_flut, l_stin
proc biophys() {
n_rn = $o1.get("section_counter").get("node")
n_mysa = $o1.get("section_counter").get("MYSA")
n_flut = $o1.get("section_counter").get("FLUT")
n_stin = $o1.get("section_counter").get("STIN")
n_mx = $o1.get("mx_n")
l_rn = $o1.get("lengths").get("node")
l_mysa = $o1.get("lengths").get("MYSA")
l_flut = $o1.get("lengths").get("FLUT")
l_stin = $o1.get("lengths").get("STIN")
nodeD = $o1.get("nodeD")
axonD = $o1.get("axonD")
fiberD = $o1.get("fiberD")
paraD1 = $o1.get("paraD1")
paraD2 = $o1.get("paraD2")
space_p1 = $o1.get("space_p1")
space_p2 = $o1.get("space_p2")
space_i = $o1.get("space_i")
rhoa = $o1.get("rhoa")
cm_ = $o1.get("cm")
nl = $o1.get("nl")
mycm = $o1.get("mycm")
mygm = $o1.get("mygm")
e_pas_ = $o1.get("IN_e_pas")
g_pas_MYSA = $o1.get("MYSA_g_pas")
g_pas_FLUT = $o1.get("FLUT_g_pas")
g_pas_STIN = $o1.get("STIN_g_pas")
Rpn0=(rhoa*1.e2)/(PI*((((nodeD/2)+space_p1)^2)-((nodeD/2)^2)))
Rpx=(rhoa*1.e2)/(PI*((((axonD/2)+space_i)^2)-((axonD/2)^2)))
Rpn1=(rhoa*1.e2)/(PI*((((paraD1/2)+space_p1)^2)-((paraD1/2)^2)))
Rpn2=(rhoa*1.e2)/(PI*((((paraD2/2)+space_p2)^2)-((paraD2/2)^2)))
for i=0, n_mx-1 {
// NODE
if (i < n_rn) {
NODE[i] {
L = l_rn.x[i]
diam = nodeD
nseg = 1
Ra = rhoa
cm = cm_
insert mrg_axnode
insert extracellular
xg[0] = 1e10
xc[0] = 0
xraxial[0] = Rpn0
}
}
// MYSA
if (i < n_mysa) {
MYSA[i] {
L = l_mysa.x[i]
diam = fiberD
nseg = 1
Ra = rhoa*(1/(paraD1/fiberD)^2)
cm = cm_*paraD1/fiberD
insert pas
e_pas = e_pas_
g_pas = g_pas_MYSA*paraD1/fiberD
insert extracellular
xg[0] = mygm/(nl*2)
xc[0] = mycm/(nl*2)
xraxial[0] = Rpn1
}
}
// FLUT
if (i < n_flut) {
FLUT[i] {
L = l_flut.x[i]
diam = fiberD
nseg = 1
Ra = rhoa*(1/(paraD2/fiberD)^2)
cm = cm_*paraD2/fiberD
insert pas
e_pas = e_pas_
g_pas = g_pas_FLUT*paraD2/fiberD
insert extracellular
xg[0] = mygm/(nl*2)
xc[0] = mycm/(nl*2)
xraxial[0] = Rpn2
}
}
// STIN
if (i < n_stin) {
STIN[i] {
L = l_stin.x[i]
diam = fiberD
nseg = 7
Ra = rhoa*(1/(axonD/fiberD)^2)
cm = cm_*axonD/fiberD
insert pas
e_pas = e_pas_
g_pas = g_pas_STIN*axonD/fiberD
insert extracellular
xg[0] = mygm/(nl*2)
xc[0] = mycm/(nl*2)
xraxial[0] = Rpx
}
}
}
}
endtemplate MRGMyelAxon