Files included in the NEURON implementation: CaDynamics_E2.mod: Ca2+ dynamics mod file Ca_HVA.mod #High-voltage activated Ca2+ current mod file Ca_LVAst.mod #Low-voltage activated Ca2+ current mod file Ih.mod #HCN channel current mod file Im.mod #Muscarinic K+ current mod file K_Pst.mod #Persistent K+ current mod file K_Tst.mod #Transient K+ current mod file NaTa_t.mod #Transient Na+ current mod file Nap_Et2.mod #Persistent Na+ current mod file SK_E2.mod #SK current mod file SKv3_1.mod #Kv3.1 channel (K+) current mod file epsp.mod #EPSC-like synaptic current mod file fullhay_run_1.dat #Reference simulation results of the full model # using a somatic stimulus fullhay_run_2.dat #Reference simulation results of the full model # using a synaptic stimulus fullhay_run_3.dat #Reference simulation results of the full model # using a somatic+synaptic stimulus fullhay_run_3a.dat #Reference simulation results of the full model # using a somatic stimulus models/fourcompartment.hoc #The model template runmodel.hoc #The hoc file for running the simulations 1, 2, 3 and 3a # (this creates run_1.dat, run_2.dat, run_3.dat data files # that you plot later) runmodel.py #The python file for running the simulations 1, 2, 3 and # 3a and plotting the results Mod and hoc-files are based on the ModelDB entry 139653 (http://modeldb.yale.edu/139653). Run the NEURON implementation and plot the results (runs.eps) by running commands: nrnivmodl python runmodel.py This script reproduces data showed in (Mäki-Marttunen et al.: "Step-wise model fitting accounting for high-resolution spatial measurements: construction of a layer V pyramidal cell model with reduced morphology", BMC Neuroscience 2016, 17(Suppl 1), p. 165): Alternatively, run without python and save the results to files run_1.dat, run_2.dat, run_3.dat and run_3a.dat: nrnivmodl nrniv runmodel.hoc