<?xml version="1.0" encoding="ISO-8859-1"?> <neuroml xmlns="http://www.neuroml.org/schema/neuroml2" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.neuroml.org/schema/neuroml2 https://raw.github.com/NeuroML/NeuroML2/development/Schemas/NeuroML2/NeuroML_v2beta4.xsd" id="SK_E2"> <notes>NeuroML file containing a single Channel description</notes> <ionChannel id="SK_E2" conductance="10pS" type="ionChannelHH" species="k"> <notes>Small-conductance, Ca2+ activated K+ current Comment from original mod file: : SK-type calcium-activated potassium current : Reference : Kohler et al. 1996</notes> <annotation> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="SK_E2"> <bqmodel:isDescribedBy xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Bag> <rdf:li>Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties, Etay Hay, Sean Hill, Felix Schürmann, Henry Markram and Idan Segev, PLoS Comp Biol 2011</rdf:li> <rdf:li rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/21829333"/> </rdf:Bag> </bqmodel:isDescribedBy> <bqbiol:isVersionOf xmlns:bqbiol="http://biomodels.net/biology-qualifiers/"> <rdf:Bag> <rdf:li>K channels</rdf:li> <rdf:li rdf:resource="http://senselab.med.yale.edu/neurondb/channelGene2.aspx#table3"/> </rdf:Bag> </bqbiol:isVersionOf> </rdf:Description> </rdf:RDF> </annotation> <gate id="z" type="gateHHtauInf" instances="1"> <timeCourse type="SK_E2_z_tau_tau"/> <steadyState type="SK_E2_z_inf_inf"/> </gate> </ionChannel> <ComponentType name="SK_E2_z_tau_tau" extends="baseVoltageConcDepTime"> <Constant name="TIME_SCALE" dimension="time" value="1 ms"/> <Constant name="VOLT_SCALE" dimension="voltage" value="1 mV"/> <Constant name="CONC_SCALE" dimension="concentration" value="1 mol_per_cm3"/> <Dynamics> <DerivedVariable name="V" dimension="none" value="v / VOLT_SCALE"/> <DerivedVariable name="ca_conc" dimension="none" value="caConc / CONC_SCALE"/> <DerivedVariable name="t" exposure="t" dimension="time" value="(1) * TIME_SCALE"/> </Dynamics> </ComponentType> <ComponentType name="SK_E2_z_inf_inf" extends="baseVoltageConcDepVariable"> <Constant name="TIME_SCALE" dimension="time" value="1 ms"/> <Constant name="VOLT_SCALE" dimension="voltage" value="1 mV"/> <Constant name="CONC_SCALE" dimension="concentration" value="1 mol_per_cm3"/> <Dynamics> <DerivedVariable name="V" dimension="none" value="v / VOLT_SCALE"/> <DerivedVariable name="ca_conc" dimension="none" value="caConc / CONC_SCALE"/> <DerivedVariable name="x" exposure="x" dimension="none" value="1/(1+(4.3e-10/ca_conc)^4.8)"/> </Dynamics> </ComponentType> </neuroml>