:Comment : The transient component of the K current
:Reference : : Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats:subtypes and gradients,Korngreen and Sakmann, J. Physiology, 2000
:Comment : shifted -10 mv to correct for junction potential
:Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21
NEURON {
SUFFIX K_Tst
USEION k READ ek WRITE ik
RANGE gK_Tstbar, gK_Tst, ik, offm, slom, offh, sloh, offmt, slomt, taummin, taumdiff,offht, sloht, tauhmin, tauhdiff
}
UNITS {
(S) = (siemens)
(mV) = (millivolt)
(mA) = (milliamp)
}
PARAMETER {
gK_Tstbar = 0.00001 (S/cm2)
offm = -10 (mV)
slom = 19 (mV)
offh = -76 (mV)
sloh = 10 (mV)
offmt = -81 (mV)
slomt = 59 (mV)
taummin = 0.34 (ms)
taumdiff = 0.92 (ms)
offht = -83 (mV)
sloht = 23 (mV)
tauhmin = 8 (ms)
tauhdiff = 49 (ms)
}
ASSIGNED {
v (mV)
ek (mV)
ik (mA/cm2)
gK_Tst (S/cm2)
mInf
mTau
hInf
hTau
}
STATE {
m
h
}
BREAKPOINT {
SOLVE states METHOD cnexp
gK_Tst = gK_Tstbar*(m^4)*h
ik = gK_Tst*(v-ek)
}
DERIVATIVE states {
rates()
m' = (mInf-m)/mTau
h' = (hInf-h)/hTau
}
INITIAL{
rates()
m = mInf
h = hInf
}
PROCEDURE rates(){
LOCAL qt
qt = 2.3^((34-21)/10)
UNITSOFF
mInf = 1/(1 + exp((offm-v)/slom))
hInf = 1/(1 + exp(-(offh-v)/sloh))
mTau = (taummin+taumdiff*exp(-((offmt-v)/slomt)^2))/qt
hTau = (tauhmin+tauhdiff*exp(-((offht-v)/sloht)^2))/qt
UNITSON
}