: HH-style KCNQ channel model
NEURON {
SUFFIX kcnq_hh
USEION k READ ek WRITE ik
RANGE g, ninf, tn, ik, gbar
GLOBAL vhn, vcn
GLOBAL Ctn, vhtn, vctn, tn0
}
UNITS {
(S) = (siemens)
(mV) = (millivolt)
(mA) = (milliamp)
}
PARAMETER {
gbar = 1 (S/cm2)
vhn = -49 (mV)
vcn = -9.7 (mV)
Ctn = 100 (ms)
vhtn = -49 (mV)
vctn = -9.7 (mV)
tn0 = 55 (ms)
Cq10 = 4
celsius (degC)
}
ASSIGNED {
g (S/cm2)
v (mV)
ninf
tn (ms)
ik (mA/cm2)
ek (mV)
}
STATE {
n
}
BREAKPOINT {
SOLVE states METHOD cnexp
g = gbar*n
ik = g*(v-ek)
}
DERIVATIVE states{
values()
n' = (ninf - n)/tn
}
INITIAL {
values()
n = ninf
}
PROCEDURE values() {LOCAL q10
q10 = Cq10^((celsius-23 (degC))/10 (degC))
ninf = 1/(1 + exp((v - vhn)/vcn))
tn = ((Ctn - tn0)/(1 + exp((v - vhtn)/vctn))) + tn0
}