/* Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJECT BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode or send a letter to Creative Commons, 171 Second Street, Suite 300, San Francisco, California, 94105, USA. */ /* * @file createsimulation.hoc * @brief Set up the simulation * @author Werner Van Geit @ BBP * @date 2015 */ load_file("nrngui.hoc") load_file("import3d.hoc") load_file("morphology.hoc") load_file("biophysics.hoc") load_file("template.hoc") //======================== settings =================================== hyp_amp = -0.071777 step_amp1 = 0.1626792 step_amp2 = 0.1762358 step_amp3 = 0.1897924 //=================== creating cell object =========================== objref cell proc create_cell() { local synapses_enabled synapses_enabled = $1 cell = new cADpyr229_L23_PC_5ecbf9b163(synapses_enabled) } //==================== recording settings ========================== objref time, voltage proc create_recording() { voltage = new Vector() time = new Vector() access cell.soma time.record(&t, 0.1) voltage.record(&v(0.5), 0.1) } //==================== stimulus settings =========================== objref hypamp_stimulus objref step_stimulus proc create_stimulus() { strdef stepcurrent stepcurrent = $s1 hypamp_stimulus = new IClamp(0.5) hypamp_stimulus.dur = tstop hypamp_stimulus.del = 0 cell.soma hypamp_stimulus step_stimulus = new IClamp(0.5) step_stimulus.dur = 2000 step_stimulus.del = 700 if (strcmp(stepcurrent, "stepcurrent1") == 0) { step_stimulus.amp = step_amp1 hypamp_stimulus.amp = hyp_amp } else if (strcmp(stepcurrent, "stepcurrent2") == 0) { step_stimulus.amp = step_amp2 hypamp_stimulus.amp = hyp_amp } else if (strcmp(stepcurrent, "stepcurrent3") == 0) { step_stimulus.amp = step_amp3 hypamp_stimulus.amp = hyp_amp } else { step_stimulus.amp = 0.0 hypamp_stimulus.amp = 0.0 } cell.soma step_stimulus } //============================= simulation ================================ proc simulate() { cvode.active(0) run() } //============================= saving results ============================ proc save_recording() { localobj timevoltage, fh timevoltage = new Matrix(time.size(), 2) timevoltage.setcol(0, time) timevoltage.setcol(1, voltage) fh = new File() fh.wopen("hoc_recordings/soma_voltage.dat") timevoltage.fprint(0, fh, "%e ") fh.close() }