#VEP Experiment 1 (Panels D-E): VEP modulation with neuromodulators on or off and with GluR1- or GluR2-type synapse CAFLUX=150.0 ALTERED=1 ALTEREDCOEFF=1.0 T=32000000 ONSET=24040000 initfile=None Ntrains=1200 LFLUXES=(0.0 5.0) GLUFLUXES=(0.0 10.0) ACHFLUXES=(0.0 10.0) BLOCKED=GluR1,GluR1_memb,GluR2,GluR2_memb for iflux in 0 1 do LFLUX=${LFLUXES[iflux]} GLUFLUX=${GLUFLUXES[iflux]} ACHFLUX=${ACHFLUXES[iflux]} for BLOCKEDCOEFF in 0.0,0.0,2.0,2.0 2.0,2.0,0.0,0.0 do if [ -f nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_membx${BLOCKEDCOEFF}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0.mat ] then echo "nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_membx${BLOCKEDCOEFF}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0.mat exists" else echo "nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_membx${BLOCKEDCOEFF}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0.mat does not exist" echo "python3 model_nrn_altered_noU.py ${T} 1e-6 $ONSET 1 100 3.0 $CAFLUX $LFLUX $GLUFLUX $ACHFLUX $Ntrains 500 $initfile $BLOCKED $BLOCKEDCOEFF $ALTERED $ALTEREDCOEFF" python3 model_nrn_altered_noU.py ${T} 1e-6 $ONSET 1 100 3.0 $CAFLUX $LFLUX $GLUFLUX $ACHFLUX $Ntrains 500 $initfile $BLOCKED $BLOCKEDCOEFF $ALTERED $ALTEREDCOEFF fi done done #VEP Experiment 2 (Panels L-T): VEP modulation with neuromodulators on with GluR1- or GluR2-type synapses, single expression variant of 5 different species LFLUX=5.0 GLUFLUX=10.0 ACHFLUX=10.0 BLOCKEDS=(Gqabg Gqabg PKC PKC PLA2 PLA2 CK CK Ng Ng NCX NCX PDE4 PDE4 PKA PKA PP1 PP1) BLOCKEDCOEFFS=(0.8 1.2 0.8 1.2 0.8 1.2 0.8 1.2 0.8 1.2 0.8 1.2 0.8 1.2 0.8 1.2 0.8 1.2) for BLOCKEDCOEFF in 0.0,0.0,2.0,2.0 2.0,2.0,0.0,0.0 do for iblock in `seq 0 17` do if [ -f nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_memb,${BLOCKEDS[iblock]}x${BLOCKEDCOEFF},${BLOCKEDCOEFFS[iblock]}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0.mat ] then echo "nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_memb,${BLOCKEDS[iblock]}x${BLOCKEDCOEFF},${BLOCKEDCOEFFS[iblock]}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0.mat exists" else echo "nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_memb,${BLOCKEDS[iblock]}x${BLOCKEDCOEFF},${BLOCKEDCOEFFS[iblock]}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0.mat does not exist" echo "python3 model_nrn_altered_noU.py ${T} 1e-6 $ONSET 1 100 3.0 $CAFLUX $LFLUX $GLUFLUX $ACHFLUX $Ntrains 500 $initfile ${BLOCKED},${BLOCKEDS[iblock]} ${BLOCKEDCOEFF},${BLOCKEDCOEFFS[iblock]} $ALTERED $ALTEREDCOEFF" python3 model_nrn_altered_noU.py ${T} 1e-6 $ONSET 1 100 3.0 $CAFLUX $LFLUX $GLUFLUX $ACHFLUX $Ntrains 500 $initfile ${BLOCKED},${BLOCKEDS[iblock]} ${BLOCKEDCOEFF},${BLOCKEDCOEFFS[iblock]} $ALTERED $ALTEREDCOEFF fi done done #MMN Experiment 3 (Panel U): VEP modulation with neuromodulators on and GluR2-type synapse, combination of CommonMind expression variants in PFC and ACC BLOCKEDS=('Calbin,CalbinC,DAGK,Gi,MGluR,NCX,Ng,PDE4,PKC,PP1' 'Calbin,CalbinC,DAGK,Gi,MGluR,NCX,Ng,PDE4,PKC,PP1' 'CK,DAGK,Gqabg,PKA' 'DAGK,PKA,PKC,PLA2,PP1' 'CK,Calbin,CalbinC,DAGK,Gi,Gqabg,MGluR,NCX,Ng,PDE4,PKA,PKC,PP1' 'Calbin,CalbinC,DAGK,Gi,MGluR,NCX,Ng,PDE4,PKA,PKC,PLA2,PP1' 'Calbin,CalbinC,DAGK,Gi,Ng,PDE4,PKC' 'DAGK,Gi,NCX,Ng,PDE4,PP1' 'CK,DAGK,Gqabg,PKA' 'DAGK,PKA,PKC,PLA2,PP1' 'CK,Calbin,CalbinC,DAGK,Gi,Gqabg,Ng,PDE4,PKA,PKC' 'DAGK,Gi,NCX,Ng,PDE4,PKA,PKC,PLA2,PP1' 'DAGK,MGluR,NCX,PDE4,PP1' 'MGluR' 'CK,DAGK,Gqabg,PKA' 'DAGK,PKA,PKC,PLA2,PP1' 'CK,DAGK,Gqabg,MGluR,NCX,PDE4,PKA,PP1' 'DAGK,MGluR,PKA,PKC,PLA2,PP1' 'DAGK,PDE4' 'CK,DAGK,Gqabg,PKA' 'DAGK,PKA,PKC,PLA2,PP1' 'CK,DAGK,Gqabg,PDE4,PKA' 'DAGK,PKA,PKC,PLA2,PP1') BLOCKEDCOEFFS=(0.967,0.967,0.974,0.979,1.062,1.060,0.973,1.054,0.994,1.066 1.025,1.025,0.988,0.968,1.093,1.021,0.941,0.967,0.984,0.986 0.905,1.140,1.109,1.079 1.158,1.055,1.056,0.864,0.897 0.905,0.967,0.967,1.029,0.979,1.109,1.062,1.060,0.973,1.054,1.079,0.994,1.066 1.025,1.025,1.045,0.968,1.093,1.021,0.941,0.967,1.055,1.020,0.864,0.942 0.985,0.985,0.924,0.971,0.962,1.012,0.996 0.992,0.984,0.999,0.944,0.977,0.992 0.959,1.072,1.063,1.048 1.134,1.039,1.037,0.933,0.940 0.959,0.985,0.985,0.998,0.971,1.063,0.962,1.012,1.048,0.996 1.039,0.984,0.999,0.944,0.977,1.039,1.037,0.933,0.966 0.918,1.062,1.090,1.054,1.066 1.093 0.905,1.140,1.109,1.079 1.158,1.055,1.056,0.864,0.897 0.905,1.029,1.109,1.062,1.090,1.054,1.079,1.066 1.158,1.093,1.055,1.056,0.864,0.897 0.924,1.012 0.959,1.072,1.063,1.048 1.134,1.039,1.037,0.933,0.940 0.959,0.998,1.063,1.012,1.048 1.134,1.039,1.037,0.933,0.940) for BLOCKEDCOEFF in 0.0,0.0,2.0,2.0 2.0,2.0,0.0,0.0 do for iblock in 10 11 do if [ -f nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_memb,CMcombx${BLOCKEDCOEFF},${iblock}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0.mat ] then echo "nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_memb,CMcombx${BLOCKEDCOEFF},${iblock}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0.mat exists" else echo "nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_memb,CMcombx${BLOCKEDCOEFF},${iblock}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0.mat does not exist" echo "python3 model_nrn_altered_noU_extfilename.py ${T} 1e-6 $ONSET 1 100 3.0 $CAFLUX $LFLUX $GLUFLUX $ACHFLUX $Ntrains 500 $initfile ${BLOCKED},${BLOCKEDS[iblock]} ${BLOCKEDCOEFF},${BLOCKEDCOEFFS[iblock]} $ALTERED $ALTEREDCOEFF nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_memb,CMcombx${BLOCKEDCOEFF},${iblock}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0" python3 model_nrn_altered_noU_extfilename.py ${T} 1e-6 $ONSET 1 100 3.0 $CAFLUX $LFLUX $GLUFLUX $ACHFLUX $Ntrains 500 $initfile ${BLOCKED},${BLOCKEDS[iblock]} ${BLOCKEDCOEFF},${BLOCKEDCOEFFS[iblock]} $ALTERED $ALTEREDCOEFF nrn_tstop32000000_tol1e-06_GluR1,GluR1_memb,GluR2,GluR2_memb,CMcombx${BLOCKEDCOEFF},${iblock}_k1x1.0_onset24040000.0_n1_freq100.0_dur3.0_flux${CAFLUX}_Lflux${LFLUX}_Gluflux${GLUFLUX}_AChflux${ACHFLUX}_Ntrains1200_trainT500.0 fi done done