TITLE SK
COMMENT
SK small conductance potassium channel
Implementation taken from:
Forrest MD (2014) Two Compartment model of the cerebellar purkinje neuron [modelDB 180789]
Purely calcium dependent
km is half-activation calcium concentration
n is Hill number
Edited by Tim Rumbell, IBM Research, 2019, thrumbel@us.ibm.com
ENDCOMMENT
NEURON {
SUFFIX sk
USEION ca READ cai
USEION k READ ek WRITE ik
RANGE gbar, oinf, n, ik
GLOBAL km:, taumod
EXTERNAL apc_metap, fpc_metap
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(molar) = (1/liter)
(mM) = (millimolar)
(S) = (siemens)
}
PARAMETER {
gbar = 1e-05 (S/cm2)
n = 4 : from many previous DA models :4.2 : from Xia 98 (including calmodulin)
km = 0.0002 (mM) : many previous DA models between 180 and 250 nM : 0.00035 (mM) : from Xia 98 (incl. calmodulin)
cai (mM)
dt (ms)
ek (mV)
: to = 15 (ms)
: taumod = 1
v (mV)
}
ASSIGNED {
ik (mA/cm2)
oinf
}
BREAKPOINT {
oinf = 1/(1 + pow(km/cai,n))
ik = oinf*gbar*(v-ek)
}