% # iAMPA_TC_PYso: % % Synaptic AMPAergic excitatory current used in (Soplata et al., 2017). % % - References: % - Soplata AE, McCarthy MM, Sherfey J, Lee S, Purdon PL, Brown EN, et al. % Thalamocortical control of propofol phase-amplitude coupling. PLoS Comput % Biol. 2017;13: e1005879. doi:10.1371/journal.pcbi.1005879 % % Tags: synapse, connection, excitation %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % Parameters gAMPA = 0.4 % mS/cm^2 EAMPA = 1 % mV % EAMPA = 0 % mV tauAMPA = 2 sAMPAIC = 0 sAMPANoiseIC= 0.1 % Connectivity % Connective radius, aka how many target cells each source cell connects % to, from the source's perspective. radius = 10 % Remove autapses to the dendrite corresponding to this soma removeRecurrentBool = 0 % We also need to normalize the conductance in mS/cm^2 by the number of % connections each target cell is receiving on average, so that the TOTAL % sum of their conductive inputs adds to our overall maximal conductance % above. normalizingFactor = min(((2*radius + (1-removeRecurrentBool)) / (N_post/N_pre)), N_pre) % Note that what is passed is 2x the radius netcon = netconNearestNeighbors(2*radius, N_pre, N_post, removeRecurrentBool) % Functions IAMPA_TC_PYso(X,sAMPA) = -gAMPA/normalizingFactor.*(sAMPA*netcon).*(X-EAMPA) monitor IAMPA_TC_PYso % ODEs and ICs sAMPA' = 5.*(1 + tanh(X_pre./4)).*(1-sAMPA) - sAMPA./tauAMPA; sAMPA(0) = sAMPAIC+sAMPANoiseIC.*rand(1,N_pre); % Linker @current += IAMPA_TC_PYso(X_post,sAMPA)