TITLE sodium leak
COMMENT
Sodium leak. This TTX sensitive sodium current is active
between spikes and has some voltage dependence (although no
inactivation that I know of) (Do & Bean 2003). I based the
voltage dependence of this channel on the Do & Bean data, but found a
pure leak had the same effect, so I stuck to the pure leak..
How the q10 works: There is a q10 for the rates (alpha and beta's)
called Q10 and a Q10 for the maximum conductance called gmaxQ10. The
q10s should have been measured at specific temperatures temp1 and
temp2 (that are 10degC apart). Ideally, as Q10 is temperature
dependant, we should know these two temperatures. We used to
follow the more formal Arrhenius derived Q10 approach. The
temperature at which this channel's kinetics were recorded is tempb
(base temperature). What we then need to calculate is the desired
rate scale for now working at temperature celsius (rate_k). This was
given by the empirical Arrhenius equation, using the Q10, but now is
using the quick Q10 approximation.
ENDCOMMENT
UNITS {
(mv) = (millivolt)
(mA) = (milliamp)
}
NEURON {
SUFFIX NaL
USEION na READ ena,nai WRITE ina
RANGE gna,inaL
GLOBAL activate_Q10,gmaxQ10,gmax_k,temp1,temp2,tempb
}
PARAMETER {
v (mV)
gna = 0.81e-5 (mho/cm2)
inaL = 0.0 (mA/cm2)
ena
nai
celsius
activate_Q10 = 1
gmaxQ10 = 1.5
temp1 = 25.0 (degC)
temp2 = 35.0 (degC)
tempb = 23.0 (degC)
}
ASSIGNED {
ina (mA/cm2)
gmax_k
}
BREAKPOINT {
ina = gna*gmax_k*(v-ena)
inaL = ina
}
UNITSOFF
INITIAL {
LOCAL ktemp,ktempb,ktemp1,ktemp2
if (activate_Q10>0) {
gmax_k = gmaxQ10^((celsius-tempb)/10)
}else{
gmax_k = 1.0
}
}
UNITSON