TITLE sodium potassium pump
: from Lindblad et al Am J Physiol 1996 275:H1666
: Original model has been modified to assume constant nai
NEURON {
SUFFIX NaKpump
USEION k READ ko WRITE ik
USEION na WRITE ina
RANGE ik, ina , INaKmax, ink, Kmko, Kmnai
GLOBAL dummy : prevent vectorization for use with CVODE
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
INaKmax = 2.45e-3 (mA/cm2) <0,1e6>
Kmnai = 27.9 (mM) <0,1e6>
Kmko = 5.3 (mM) <0,1e6>
nai = 10 (mM)
}
ASSIGNED {
celsius (degC)
v (mV)
ko (mM)
ik (mA/cm2)
ina (mA/cm2)
ink (mA/cm2)
dummy
}
BREAKPOINT { LOCAL q10 , fnk
q10 = 3^((celsius - 37)/10 (degC))
fnk = (v + 150)/(v + 200)
ink= q10*INaKmax*fnk/((1 + (Kmnai/nai)^1.5)*(1 + Kmko/ko))
ina = 3*ink
ik = -2*ink
}