COMMENT
Longitudinal diffusion of potassium
(equivalent modified euler with standard method and
equivalent to diagonalized linear solver with CVODE )
ENDCOMMENT
NEURON {
SUFFIX kdifl
USEION k READ ik WRITE ko
RANGE ko, Dk, sp, rseg
}
UNITS {
(molar) = (1/liter)
(mM) = (millimolar)
(um) = (micron)
(mA) = (milliamp)
FARADAY = (faraday) (coulomb)
PI = (pi) (1)
}
PARAMETER {
Dk = 1.85 (um2/ms)
sp = 0.01 (um)
rseg = 1.7 (um)
extracellularVolumePerLength (um2)
crossSectionalArea (um2)
}
ASSIGNED { ik (mA/cm2) }
STATE { ko (mM) }
INITIAL {
extracellularVolumePerLength = PI * ( (rseg+sp)^2 - rseg^2 )
crossSectionalArea = extracellularVolumePerLength
}
BREAKPOINT { SOLVE conc METHOD sparse }
KINETIC conc {
COMPARTMENT extracellularVolumePerLength {ko}
LONGITUDINAL_DIFFUSION Dk*crossSectionalArea {ko}
~ ko << (ik/(FARADAY)*2*PI*rseg*(1e4))
}