COMMENT
Longitudinal and radial diffusion of potassium
ENDCOMMENT
NEURON {
SUFFIX kdifrl
USEION k READ ik WRITE ko
RANGE ko, Dk, sp
}
UNITS {
(molar) = (1/liter)
(mM) = (millimolar)
(um) = (micron)
(mA) = (milliamp)
FARADAY = (faraday) (coulomb)
PI = (pi) (1)
}
PARAMETER {
Dk = 1.85 (um2/ms)
nodalGap = 1.9 (um)
rn = 0.95 (um)
extracellularVolumePerLength (um2)
crossSectionalArea (um2)
kbathVolumePerLength = 1e15 (um2)
radialCrosssectionalAreaPerLength (um)
radialRateConstant (um2/ms)
kbath = 3 (mM)
}
ASSIGNED { ik (mA/cm2) }
STATE { ko (mM) }
INITIAL {
extracellularVolumePerLength =PI * ( (rn+nodalGap)^2 - rn^2 )
crossSectionalArea = extracellularVolumePerLength
radialCrosssectionalAreaPerLength = 2 * PI * ( rn + nodalGap )
radialRateConstant = Dk * radialCrosssectionalAreaPerLength / nodalGap
}
BREAKPOINT { SOLVE conc METHOD sparse }
KINETIC conc {
COMPARTMENT crossSectionalArea { ko }
COMPARTMENT kbathVolumePerLength { kbath }
LONGITUDINAL_DIFFUSION Dk*extracellularVolumePerLength { ko }
~ ko << (ik/(FARADAY)*2*PI*rn*(1e4))
~ ko <-> kbath (radialRateConstant,radialRateConstant)
}