% ki: simple first-order model of potassium (k+) accumulation dynamics (ref: Durstewitz and Sejnowski 2000) %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % Parameters koinf = 3.82 % mM, equilibrium k+ concentration tauK = 7 % ms, decay time constant KAF = 2 % potassium accumulation factor VshellK=250; % volume of shell for k+ diffusion faraday=96485 % ms*A/mmol, Faraday constant % note: small tauK -> ko follows @ik with minimal k+ accumulation IC_noise=0 % ODEs ko' = KAF.*@ik./(faraday*VshellK)+(koinf-ko)./tauK ko(0) = koinf+IC_noise.*rand(1,Npop) % Interface @ko += ko % http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101327/ %ko' = @ik/3210+(koinf-ko)/750 %ko' = .3115e-3*@ik+1.333e-3*(koinf-ko) %ko' = (@ik/3.21+(koinf-ko)/.75)/1000 %ko' = @ik/3.21+(koinf-ko)/.75 %ko' = .0445*7*@ik+1.333*(koinf-ko) %ko' = .01*@ik+(koinf-ko)/7 %ko' = @ik/100+(koinf-ko)/7 %ko' = @ik/32.10+(koinf-ko)/7.50