% High-voltage-activated Calcium current (Durstewitz, Seamans, Sejnowski 2000; iHVA) % [DS02] inactivation was sped up by a factor of 3; same for [DS06] % Parameters ghva=.34; %1; % .34 (PY soma); .7 (PY prox dend) cao=2; % mM, extracellular calcium concentration, 2 or 4 IC_noise=0; wtauHVA=420/3; % Functions uinf(X)=1./(1+exp(-(X+24.6)/11.3)) utau(X)=1.25*sech(-.031*(X+37.1)) winf(X)=1./(1+exp((X+12.6)/18.9)) wtau(X)=wtauHVA ECa(@cai)=min(500,12.5*log(cao./@cai)) IHVA(X,u,w,@cai)=ghva.*u.^2.*w.*(X-ECa(@cai)) % ODEs and ICs u'=(uinf(X)-u)./utau(X) w'=(winf(X)-w)./wtau(X) u(0)=uinf(-65)+IC_noise.*rand(1,Npop) w(0)=winf(-65)+IC_noise.*rand(1,Npop) % Linkers @current += -IHVA(X,u,w,@cai) @ica += IHVA(X,u,w,@cai) %aw(X)=winf(X)./wtau(X) %bw(X)=(1-winf(X))./wtau(X) %w'=aw(X).*(1-w)-3*bw(X).*w