function data = dsCalcFRmulti(data, varargin)
%dsCalcFRmulti - extends dsCalcFR to get SUA and MUA firing rates
%
% Usage:
% data = dsCalcFRmulti(data,'option',value)
%
% Inputs:
% - data: DynaSim data structure (see dsCheckData)
% - options:
% 'variable' : name of field containing data on which to calculate
% firing rates (default: *_spikes or first variable in data.labels)
% 'time_limits' : [beg,end] (units of data.time)
% 'threshold' : scalar threshold value for detecting events (default: 0)
% 'bin_size' : size of temporal window over which to calculate rate
% [ms or fraction of data set] (default: 5% of the data set)
% 'bin_shift' : how much to shift the bin before calculating rate again [ms
% or fraction of data set] (default: 1% of the data set)
% 'exclude_data_flag': whether to remove simulated data from result
% structure (default: 0)
% 'output_suffix' : suffix to attach to output variable names (default: '')
%
% Outputs:
% - data: data structure with firing rates [Hz] in .variable_FR
%
% Notes:
% - "variable" can be specified as the name of a variable listed in
% data.labels, a cell array of string listing variable names, or as a
% regular expression pattern for identifying variables to process.
% See dsSelectVariables for more info on supported specifications.
% - DynaSim spike monitor returns spike data in variables *_spikes.
% - e.g., `data=dsSimulate('dv/dt=@current+10; {iNa,iK}; monitor v.spikes');`
% returns spikes in data.pop1_v_spikes (where 'pop1' is the default
% population name if not specified by the user).
%
% Examples:
% s.populations(1).name='E';
% s.populations(1).equations='dv/dt=@current+10; {iNa,iK}; v(0)=-65';
% s.populations(2).name='I';
% s.populations(2).equations='dv/dt=@current+10; {iNa,iK}; v(0)=-65';
% data=dsSimulate(s);
% data=dsCalcFRmulti(data,'variable','*_v');
% data % contains firing rates for E and I pops in .E_v_FR_SUA/MUA and .I_v_FR_SUA/MUA.
%
% See also: dsCalcFR. dsPlotFR, dsAnalyzeStudy, dsSimulate, dsCheckData, dsSelectVariables
%% 1.0 Check inputs
options=dsCheckOptions(varargin,{...
'variable','',[],...
'time_limits',[-inf inf],[],...
'threshold',1e-5,[],... % slightly above zero in case variable is point process *_spikes {0,1}
'bin_size',.05,[],...
'bin_shift',.01,[],...
'exclude_data_flag',0,{0,1},...
'output_suffix','',[],...
'auto_gen_test_data_flag',0,{0,1},...
},false);
%% auto_gen_test_data_flag argin
if options.auto_gen_test_data_flag
varargs = varargin;
varargs{find(strcmp(varargs, 'auto_gen_test_data_flag'))+1} = 0;
varargs(end+1:end+2) = {'unit_test_flag',1};
argin = [{data}, varargs]; % specific to this function
end
data = dsCheckData(data, varargin{:});
% note: calling dsCheckData() at beginning enables analysis function to
% accept data matrix [time x cells] in addition to DynaSim data structure.
if numel(data)>1
% use dsAnalyzeStudy to recursively call dsCalcFRmulti on each data set
data=dsAnalyzeStudy(data,@dsCalcFRmulti,varargin{:});
return;
end
% time info
time = data.time;
dt = time(2)-time(1); % ms
ntime=length(time);
t1=nearest(time,options.time_limits(1)); % index to first sample
t2=nearest(time,options.time_limits(2)); % index to last sample
ntime=t2-t1+1;
% set defaults
% default variable to process
if isempty(options.variable)
if any(~cellfun(@isempty,regexp(data.labels,'_spikes$')))
% use results from DynaSim spike monitor
options.variable=data.labels(~cellfun(@isempty,regexp(data.labels,'_spikes$')));
if length(options.variable)==1 % store in string
options.variable=options.variable{1};
end
else
% use first state variable in model
%options.variable=data.labels{1};
end
end
% check bin_size
if options.bin_size > 1
% convert from ms to index points
options.bin_size = ceil(options.bin_size / dt);
binMsBool = true;
else
% convert from fraction to index points
options.bin_size = ceil(options.bin_size * ntime);
binMsBool = false;
end
% now options.bin_size in units of index points
% constrain bin_size to entire data set
if options.bin_size > ntime
options.bin_size = ntime;
end
% check bin_shift
if options.bin_shift > 1 || binMsBool
% convert from ms to index points
options.bin_shift = ceil(options.bin_shift / dt);
else
% convert from fraction to index points
options.bin_shift = ceil(options.bin_shift * ntime);
end
%% 2.0 set list of variables to process as cell array of strings
options.variable = dsSelectVariables(data(1),options.variable, varargin{:});
%% 3.0 calculate firing rates for each variable
if ~isfield(data,'results')
data.results={};
end
% 3.1 calc bin info
% samples at which bins begin
bin_index_begs = t1:options.bin_shift:t2;
% samples at which bins end
bin_index_ends = bin_index_begs + options.bin_size;
if bin_index_ends(end)>t2
if length(bin_index_ends) > 1 %multiple bins
% remove final bin if extends beyond data (index == t2)
bin_index_begs = bin_index_begs(bin_index_ends <= t2);
bin_index_ends = bin_index_ends(bin_index_ends <= t2);
else %1 bin
bin_index_ends = t2;
end
end
% times at which bins begin
bin_times = time(bin_index_begs);
% number of bins
nbins = length(bin_index_begs);
% time width of a single bin in seconds
bin_width = (dt/1000)*options.bin_size;
% 3.2 loop over variables to process
for v=1:length(options.variable)
% extract this data set
var=options.variable{v};
dat=data.(var);
% determine how many cells are in this data set
ncells=size(dat,2);
% loop over cells
FR_SUA=zeros(nbins,ncells);
FR_MUA=zeros(nbins,1);
% spike_times=cell(1,ncells);
% spike_inds = zeros(ntime, ncells);
% for i=1:ncells
% % get spikes in this cell
% spike_inds=1+find((dat(2:end,i)>=options.threshold & dat(1:end-1,i)<options.threshold));
% spikes=zeros(ntime,1);
% spike_times{i}=time(spike_inds);
% end
spikes = [zeros(1,ncells); (dat(2:end,:)>=options.threshold & dat(1:end-1,:)<options.threshold)];
if any(spikes(:))
% calculate firing rates
for bin=1:nbins
% (# spikes in bin) / (duration of bin in seconds)
FR_SUA(bin,:) = sum(spikes(bin_index_begs(bin):bin_index_ends(bin), :))/bin_width;
FR_MUA(bin) = sum(sum(spikes(bin_index_begs(bin):bin_index_ends(bin), :))) / (bin_width * ncells); % MUA average
end
end
% add firing rates to data structure
data.([var '_FR_SUA' options.output_suffix]) = FR_SUA;
data.([var '_FR_MUA' options.output_suffix]) = FR_MUA;
% data.([var '_spike_times'])=spike_times;
if ~ismember([var '_FR_SUA' options.output_suffix], data.results)
data.results{end+1}=[var '_FR_SUA' options.output_suffix];
% data.results{end+1}=[var '_spike_times'];
end
if ~ismember([var '_FR_MUA' options.output_suffix], data.results)
data.results{end+1}=[var '_FR_MUA' options.output_suffix];
end
end
% add bin times to data
data.(['time_FR' options.output_suffix]) = bin_times;
if ~ismember(['time_FR' options.output_suffix], data.results)
data.results{end+1}=['time_FR' options.output_suffix];
end
if options.exclude_data_flag
for l=1:length(data.labels)
data=rmfield(data,data.labels{l});
end
end
%% auto_gen_test_data_flag argout
if options.auto_gen_test_data_flag
argout = {data}; % specific to this function
dsUnitSaveAutoGenTestData(argin, argout);
end