% iCaT: T-type Calcium current, Hodgkin-Huxley-style, for generic % thalamocortical relay cells, corresponding to CaV 3.1 % % Reference: % - Ching, S., Cimenser, A., Purdon, P. L., Brown, E. N., & Kopell, N. J. % (2010). Thalamocortical model for a propofol-induced alpha-rhythm associated % with loss of consciousness. Proceedings of the National Academy of Sciences, % 107(52), 22665-22670. doi:10.1073/pnas.1017069108 % % Requires: calcium concentration "@CaBufferChing" (exposed by "CaBufferChing" mechanism) % Exposes: calcium current "@ICaT" for other mechanisms (e.g. required by "CaBufferChing" mechanism) % Tags: calcium, current, intrinsic, thalamus %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % Parameters gT = 2 % mS/cm^2 v_shift = 2 % mV phiH = 3.73 % unitless, based on Q10 of 3 % Functions ET(CaBufferChing) = 1000.*((8.31441.*309.15)./(2.*96846)).*log(2./(CaBufferChing)) % mV Minf(X) = 1./(1+exp((-((X+v_shift)+57))./6.2)) Hinf(X) = 1./(1+exp(((X+v_shift)+81)./4)) tauH(X) = (30.8+(211.4+exp(((X+v_shift)+113.2)./5))./(1+exp(((X+v_shift)+84)./3.2)))./phiH ICaT(X,hT) = gT.*Minf(X).^2.*hT.*(X-ET(@CaBufferChing)) monitor ICaT % ODEs and ICs hT' = (Hinf(X)-hT)./tauH(X); hT(0)=.34+.1.*rand(1,Npop); % Interface @current += -ICaT(X,hT) @ICaT += ICaT(X,hT)