%% iH: Hyperpolarization-activated H-current, Hodgkin-Huxley-style, for generic % thalamocortical relay cells, using the (Ching et al., 2010) adaptation of the % (Destexhe et al., 1996) H-current. % References: % - Ching, S., Cimenser, A., Purdon, P. L., Brown, E. N., & Kopell, N. J. % (2010). Thalamocortical model for a propofol-induced alpha-rhythm associated % with loss of consciousness. Proceedings of the National Academy of Sciences, % 107(52), 22665-22670. doi:10.1073/pnas.1017069108" % - Destexhe, A., Bal, T., McCormick, D. A., & Sejnowski, T. J. (1996). Ionic % mechanisms underlying synchronized oscillations and propagating waves in a % model of ferret thalamic slices. Journal of Neurophysiology, 76(3), 2049–2070. % % Requires: calcium concentration "@CaBufferChing" (exposed by "CaBufferChing" mechanism) % % Tags: calcium, current, intrinsic, thalamus %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % Parameters gH = 0.005 % mS/cm^2 EH = -43 % mV % Functions tauS(X) = 20 + 1000./(exp((X+71.5)./14.2)+exp((-(X+89))./11.6)) Hinf(X) = 1./(1+exp((X+75)./5.5)) aH(X) = Hinf(X)./tauS(X) bH(X) = (1-Hinf(X))./tauS(X) IH(X,Cone,Pzero,OPENone) = gH.*(OPENone+2.*(1-Cone-OPENone)).*(X-EH) % Record all the things! monitor IH % ODEs and ICs Cone' = bH(X).*OPENone - aH(X).*Cone; Cone(0) = 0.5.*rand(1,Npop); % Note: here, it uses the external @CaBufferChing Pzero' = 0.0004.*(1-Pzero) - 0.0004.*((@CaBufferChing./0.002).^4).*Pzero; Pzero(0) = 0.5.*rand(1,Npop); OPENone' = 0.001.*(1-Cone-OPENone) - 0.001.*((1-Pzero)./0.01).*OPENone; OPENone(0) = 0.*rand(1,Npop); % Linker @current += -IH(X,Cone,Pzero,OPENone)