% iM: muscarinic receptor suppressed, slow, noninactivating potassium current (ref: Kramer/Kopell 2008) % Tags: M-current, potassium, channel, intrinsic %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % Parameters gM=.75; E_M=-95; c_MaM=1; c_MbM=1 IC=0; IC_noise=0 % Functions aM(X) = c_MaM.*(.02./(1+exp((-20-X)/5))) # [Traub, 2003] bM(X) = c_MbM.*(.01*exp((-43-X)/18)) # [Traub, 2003] IM(X,m) = -gM.*m.*(X-E_M) % ODEs mM' = (aM(X).*(1-mM)-bM(X).*mM) mM(0)=IC+IC_noise.*rand(1,Npop) % Interface @current += IM(X,mM) %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % References: % Kramer, M. A., Roopun, A. K., Carracedo, L. M., Traub, R. D., Whittington, M. A., & Kopell, N. J. (2008). Rhythm generation through period concatenation in rat somatosensory cortex. PLoS computational biology, 4(9), e1000169. (http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000169) % Traub RD, Buhl EH, Gloveli T, Whittington MA (2003) Fast rhythmic bursting can be induced in layer 2/3 cortical neurons by enhancing persistent Na+ conductance or by blocking BK channels. J Neurophysiol 89:909–921.