TITLE I-h channel from Magee 1998 for distal dendrites
: default values are for dendrites and low Na
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
e (mV)
celsius (degC)
gmax=.0001 (mho/cm2)
vhalfl=-90 (mV) : very insensitive to this param
vhalft=-75 (mV) : very insensitive to this param, although at both -200 and 0, it is much different
a0t= .007 (/ms) : .005 (/ms) : 0.011 (/ms)
zetal= 2 (1) :5 (1) : 2 (1) :4 (1) : smaller values makes back slope of sag shallower, steady state more hyperpol
zetat= 1.1 (1) : 1.1 (1) : 2.2 (1) : 2.2 (1) :(larger values make sag smaller, steady state more hyperpol)
gmt=.4 (1): .2 (1) :.2 (1) :.4 (1)
q10=4.5
qtl=1
myslope=0.07 :0.0378
}
NEURON {
SUFFIX ch_HCNp
NONSPECIFIC_CURRENT i
RANGE gmax, vhalfl, myi, e
GLOBAL linf,taul
}
STATE {
l
}
ASSIGNED {
i (mA/cm2)
myi (mA/cm2)
linf
taul
g
}
INITIAL {
rate(v)
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
g = gmax*l
i = g*(v-e)
myi = i
}
FUNCTION alpl(v(mV)) {
alpl = exp(myslope*zetal*(v-vhalfl))
}
FUNCTION alpt(v(mV)) {
alpt = exp(myslope*zetat*(v-vhalft))
}
FUNCTION bett(v(mV)) {
bett = exp(myslope*zetat*gmt*(v-vhalft))
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rate(v)
l' = (linf - l)/taul
}
PROCEDURE rate(v (mV)) { :callable from hoc
LOCAL a,qt
qt=q10^((celsius-33)/10)
a = alpt(v)
linf = 1/(1+ alpl(v))
taul = bett(v)/(qtl*qt*a0t*(1+a))
}