TITLE I-h channel from Magee 1998 for distal dendrites
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
ehd (mV)
celsius (degC)
ghdbar=.0001 (mho/cm2)
vhalfl=-100 (mV)
kl=-12
vhalft=-75 (mV)
a0ta=0.001 (/ms)
a0td=0.009 (/ms)
zetat=2.2 (1)
gmt=.4 (1)
q10=4.5
qtl=1
}
NEURON {
SUFFIX hd
NONSPECIFIC_CURRENT i
RANGE ghdbar, vhalfl, tau
GLOBAL linf,taua, taud
}
STATE {
l
}
ASSIGNED {
i (mA/cm2)
linf
tau
taua
taud
ghd
}
INITIAL {
rate(v)
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ghd = ghdbar*l
i = ghd*(v-ehd)
}
FUNCTION alpt(v(mV)) {
alpt = exp(0.0378*zetat*(v-vhalft))
}
FUNCTION bett(v(mV)) {
bett = exp(0.0378*zetat*gmt*(v-vhalft))
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rate(v)
if (l<linf) {tau=taua} else {tau=taud}
l' = (linf - l)/tau
}
PROCEDURE rate(v (mV)) { :callable from hoc
LOCAL a,qt
qt=q10^((celsius-33)/10)
a = alpt(v)
linf = 1/(1 + exp(-(v-vhalfl)/kl))
taua = bett(v)/(qtl*qt*a0ta*(1+a))
taud = bett(v)/(qtl*qt*a0td*(1+a))
}