TITLE HH k channel channel
: Hodgkin - Huxley k channel
: The model used in Safronov et al. 2000
NEURON {
SUFFIX B_DR
USEION k READ ek WRITE ik
RANGE gkbar, ik
RANGE ninf, ntau
RANGE tadj
}
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
STATE {
n
}
PARAMETER {
ek = -84 (mV)
}
ASSIGNED {
celsius (degC)
v (mV)
ik (mA/cm2)
: ek (mV): -84 mV
gkbar (mho/cm2)
tadj (1)
nalpha (1/ms)
nbeta (1/ms)
ninf (1)
ntau (ms)
}
INITIAL {
rates(v)
tadj = 3^((celsius - 23)/10)
n = ninf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ik = gkbar*n*n*n*n*(v - ek)
}
DERIVATIVE states{
rates(v)
n' = (ninf-n)/ntau
}
:catch 0 in denominator
FUNCTION trap(x,y) {
if (fabs(x/y) < 1e-6) {
trap = y*(1 - x/y/2)
}else{
trap = x/(exp(x/y) - 1)
}
}
PROCEDURE rates(v) {
TABLE ninf, ntau DEPEND celsius FROM -100 TO 100 WITH 200
nalpha = .0075*trap(-v - 30, 10)
nbeta = .1*exp((-v - 46)/31)
ninf = nalpha / (nalpha + nbeta)
ntau = 1/(nalpha + nbeta)
}