COMMENT
K channel for the fly lobular plate VS cell. Based on the paper:
Haah, theunissen and Borst (1997) "The intrinsic electrophysiological characteristics of fly lobular plate tangential cells: II Active memberane properties".
J. Comp. Neurosc. 4:349-369
Author B. Torben-Nielsen @ TENU/OIST. 2009-01-13 (with help from T. Carnevale)
ENDCOMMENT
NEURON {
SUFFIX emdk
USEION k READ ek WRITE ik
RANGE gk, gbar, i
RANGE ninf, ntau : would be OK for these to be GLOBAL
GLOBAL nmidv, nslope, ntaumax, nmidvdn, nslopedn, nmidvup, nslopeup
}
UNITS { : units that are not in the units database should be declared here
(mV) = (millivolt)
(mA) = (milliamp)
(uA) = (microamp)
(S) = (siemens)
}
PARAMETER {
: set to the values described in the aforementioned paper
ek = -20 (mV) : this value will have no effect. set in hoc code
gbar = 0.001 (S/cm2)
nmidv = 14 (mV)
nslope = 11 (mV)
ntaumax = 50.2 (ms)
nmidvdn = 25 (mV)
nslopedn = -30 (mV)
nmidvup = 28 (mV)
nslopeup = 32 (mV)
}
ASSIGNED {
: either assigned by the system (e.g., v and i) or by us
v (mV)
i (mA/cm2)
ik (mA/cm2)
gk (S/cm2)
ninf
ntau (ms)
}
STATE { n }
INITIAL {
rates(v)
n = ninf
}
BREAKPOINT {
SOLVE states METHOD cnexp
gk = gbar*n*n*n*n :n^4
i = gk * (v - ek) : for convenience, "i" is declared as range so that it can be studied as a seperate current coming from this mechanism.
ik = i
}
DERIVATIVE states {
rates(v)
n' = (ninf - n)/ntau
}
PROCEDURE rates(v (mV))
{
ninf = 1/ ( 1 + exp( (nmidv-v)/nslope ) )
ntau = ntaumax / ( exp( (nmidvdn-v)/nslopedn ) + exp( (nmidvup-v)/nslopeup ) )
: ntau = ntau / ntaumax : EXTRA. ONLY FOR TESTING PURPOSES
}