COMMENT
Na dependent K channel for the fly lobular plate VS cell. This channel has a sigmoidal dependence on
the actual Na current present.
Based on the paper:
Haag, Theunissen and Borst (1997) "The intrinsic electrophysiological characteristics of fly lobular plate tangential cells: II Active memberane properties".
J. Comp. Neurosc. 4:349-369
Author B. Torben-Nielsen @ TENU/OIST. 2009-01-13 (with help from T. Carnevale)
ENDCOMMENT
NEURON {
SUFFIX emdkna
USEION k READ ek WRITE ik
USEION na READ ina
RANGE gk, gbar, i
RANGE ninf, ntau : would be OK for these to be GLOBAL
GLOBAL slope,taumax
}
UNITS { : units that are not in the units database should be declared here
(mV) = (millivolt)
(mA) = (milliamp)
(uA) = (microamp)
(S) = (siemens)
}
PARAMETER {
ek = -20 (mV) : this value will have no effect
gbar = 0.002 (S/cm2)
: midV from the paper can be left out because it is 0
slope = 7 (uA/cm2)
taumax = 3 (ms)
ntau = 3 (ms) : constant
}
ASSIGNED {
v (mV) : must declare v
i (mA/cm2)
ik (mA/cm2)
gk (S/cm2)
ninf
ina (mA/cm2) : for a density mechanism, ionic currents are in (mA/cm2)
}
STATE { n }
INITIAL {
rates(ina)
n = ninf
}
BREAKPOINT {
SOLVE states METHOD cnexp
gk = gbar*n*n*n*n : n^4
i = gk * (v - ek)
ik = i
}
DERIVATIVE states {
rates(ina)
n' = (ninf - n)/ntau
}
PROCEDURE rates(ina (mA/cm2)) {
ninf = 1 / ( 1 + exp( -ina/((1e-3)*slope) ) ) : (1e-3) converts uA/cm2 to mA/cm2
}