COMMENT
Na channel for the fly lobular plate VS cell. Based on the paper:
Haah, theunissen and Borst (1997) "The intrinsic electrophysiological characteristics of fly lobular plate tangential cells: II Active memberane properties".
J. Comp. Neurosc. 4:349-369
Author B. Torben-Nielsen @ TENU/OIST. 2009-01-13 (with help from T. Carnevale)
ENDCOMMENT
NEURON {
SUFFIX emdna
USEION na READ ena WRITE ina
RANGE gna, gbar, i
RANGE minf, hinf, mtau, htau : would be OK for these to be GLOBAL
GLOBAL hmidv, hslope, htaumax, hmidvdn, hslopedn, hmidvup, hslopeup
GLOBAL mmidv, mslope, mtaumax, mmidvdn, mslopedn, mmidvup, mslopeup
}
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
(uA) = (microamp)
(S) = (siemens)
}
PARAMETER {
ena = 100 (mV) : this value will have no effect
gbar = 0.003 (S/cm2)
mmidv = -1 (mV)
mslope = 6 (mV)
mtaumax = 1.8 (ms)
mmidvdn = -31 (mV)
mslopedn = -25 (mV)
mmidvup = -60 (mV)
mslopeup = 11 (mV)
hmidv = -11 (mV)
hslope = -8 (mV)
htaumax = 9 (ms)
hmidvdn = -4 (mV)
hslopedn = -12 (mV)
hmidvup = -16 (mV)
hslopeup = 14 (mV)
}
ASSIGNED {
v (mV)
i (mA/cm2)
ina (mA/cm2)
gna (mho/cm2)
minf
hinf
mtau (ms)
htau (ms)
}
STATE { m h }
INITIAL {
rates(v)
m = minf
h = hinf
}
BREAKPOINT {
SOLVE states METHOD cnexp
gna = gbar*m*m*m*h
i = gna * (v - ena)
ina = i
}
DERIVATIVE states {
rates(v)
m' = (minf - m)/mtau
h' = (hinf - h)/htau
}
PROCEDURE rates(v (mV)) {
: first for the "m" variable
minf = 1/ ( 1 + exp( (mmidv-v)/mslope ) )
mtau = mtaumax / ( exp( (mmidvdn-v)/mslopedn ) + exp( (mmidvup-v)/mslopeup ) )
: mtau = mtau / mtaumax : EXTRA. ONLY FOR TESTING PURPOSES
: then for the "h" variable
hinf = 1/ ( 1 + exp( (hmidv-v)/hslope ) )
htau = htaumax / ( exp( (hmidvdn-v)/hslopedn ) + exp( (hmidvup-v)/hslopeup ) )
: htau = htau / htaumax : EXTRA. ONLY FOR TESTING PURPOSES
}