COMMENT
high-threshold calcium channel from Av-Ron and Vidal, 1999
Implemented by C. Weaver, 2003
ENDCOMMENT
UNITS {
(molar) = (1/liter)
(mM) = (millimolar)
(mA) = (milliamp)
(mV) = (millivolt)
}
NEURON {
SUFFIX cahi
USEION ca READ eca WRITE ica
RANGE gbar
GLOBAL xinf
RANGE tot
}
PARAMETER {
v (mV)
celsius (degC)
: gbar=.001 (mho/cm2)
gbar = 0.0002 (mho/cm2)
: cai (mM)
: cao (mM)
xtau=5 (ms)
Kc=1 (mM)
ax=0.08 (/mV)
vhx=-30 (mV)
vrest = 124 (mV)
simp = 0
}
STATE {
x
}
ASSIGNED {
ica (mA/cm2)
tot (mA/cm2)
cai (mM)
gca (mho/cm2)
xinf
eca (mV)
}
INITIAL {
rate(v)
x = xinf
: printf("cahi ica=%g\n",ica)
}
BREAKPOINT {
SOLVE state METHOD cnexp
gca = gbar*x*x*Kc/(Kc+cai)
tot = gca*(v-eca)
if( simp > 0 ) {
: Av-Ron 1991, simpler
gca = gbar*x
: gca = gbar*x*x
}
: ica = gca*(v-vrest)
ica = gca*(v-eca)
}
FUNCTION expn(v (mV),a(/mV), vhalf(mV)) {
expn = exp(-2*a*(v-vhalf))
}
DERIVATIVE state {
rate(v)
x' = (xinf - x)/xtau
}
PROCEDURE rate(v (mV)) { :callable from hoc
xinf = 1/(1 + expn(v,ax,vhx))
}