/*---------------------------------------------------------------- Geometry file for thalamic reticular neuron - 3 compartments - 1 soma, 1 proximal dendrite, 1 distal dendrite Obtained from merging the cell from rat nRt, stained by Huguenard & Prince, Stanford. The cell was traced in the Salk Institute by A. Destexhe. Starting from a 800 compartment cell, the geometry was reduced into an equivalent geometry of 10 compartments, by the method of Bush & Sejnowski (J Neurosci Methods 46: 159-166, 1993). In a second step, the 10-compartment geometry was merged into 3 compartments using the same method. Structure of the reduced compartmental model: 1--0 1--0 1--0 (dend1) (soma) Length and diameters: --------------------- Soma : L=34.546 diam=14.075 S=1527.55 dend1[0] : L=103.24 diam=5.56 S=1803.32 dend1[1] : L=190.69 diam=3.06 S=3636.475 => total dendritic surface = 5439.794 um2 The reconstructed cell was 13302.9 um2 => reduction factor for dendrites is 2.445 Input resistance: ----------------- dendritic correction Ri (Mohms) 1 400 2.445 214 3 180 3.5 158 4 143 For more details, see: Destexhe, A., Contreras, D., Steriade, M., Sejnowski, T.J. and Huguenard, J.R. In vivo, in vitro and computational analysis of dendritic calcium currents in thalamic reticular neurons. J. Neurosci. 16: 169-185, 1996. See also: http://www.cnl.salk.edu/~alain http://cns.fmed.ulaval.ca ----------------------------------------------------------------*/ print "----------------------------------------------" print "Simplified reticular cell with 3 compartments" print "----------------------------------------------" /* create compartments (sections) */ create soma[1], \ dend1[2] /* connect compartments */ soma connect dend1[0](0),1 dend1[0] connect dend1[1](0),1 /* setup 3d geometry : */ soma { /* define soma first */ nseg = 1 pt3dclear() pt3dadd(0, 0, 0, 14.0754) /* x,y,z,diam */ pt3dadd(0, 34.546, 0, 14.0754) } dend1[0] { /* beginning dendrites */ nseg = 1 pt3dclear() pt3dadd(0, 34.546, 0, 5.56) pt3dadd(0, 137.786, 0, 5.56) } dend1[1] { /* beginning dendrites */ nseg = 1 pt3dclear() pt3dadd(0, 137.786, 0, 3.06) pt3dadd(0, 328.476, 0, 3.06) }