TITLE na3 : Na current : from Jeff M. : ---------- modified -------M.Migliore may97 NEURON { SUFFIX na3 USEION na READ ena WRITE ina RANGE gbar, i :, ar2 GLOBAL minf, hinf, mtau, htau, qinf, thinf } PARAMETER { gbar = 0.010 (mho/cm2) tha = -30 (mV) : v 1/2 for act qa = 7.2 (mV) : act slope (4.5) Ra = 0.4 (/ms) : open (v) Rb = 0.124 (/ms) : close (v) thi1 = -45 (mV) : v 1/2 for inact thi2 = -45 (mV) : v 1/2 for inact qd = 1.5 (mV) : inact tau slope qg = 1.5 (mV) mmin=0.02 hmin=0.5 q10=2 Rg = 0.01 (/ms) : inact recov (v) Rd = .03 (/ms) : inact (v) qq = 10 (mV) tq = -55 (mV) thinf = -50 (mV) : inact inf slope qinf = 4 (mV) : inact inf slope ar2=1 (1) : 1=no inact., 0=max inact. ena (mV) : must be explicitly def. in hoc celsius v (mV) } UNITS { (mA) = (milliamp) (mV) = (millivolt) (pS) = (picosiemens) (um) = (micron) } ASSIGNED { ina (mA/cm2) i (mA/cm2) thegna (mho/cm2) minf hinf mtau (ms) htau (ms) tha1 } STATE { m h} BREAKPOINT { SOLVE states METHOD cnexp thegna = gbar*m*m*m*h ina = thegna * (v - ena) i = ina } INITIAL { trates(v,ar2) m=minf h=hinf } LOCAL mexp, hexp DERIVATIVE states { trates(v,ar2) m' = (minf-m)/mtau h' = (hinf-h)/htau } PROCEDURE trates(vm,a2) { LOCAL a, b, qt qt = 1.6245 tha1 = tha a = trap0(vm,tha1,Ra,qa) b = trap0(-vm,-tha1,Rb,qa) mtau = 1/(a+b)/qt if (mtau 1e-6) { trap0 = a * (v - th) / (1 - exp(-(v - th)/q)) } else { trap0 = a * q } }