# CelegansInterMotorNeuronsModels

The folder contains the codes for reproducing the figures of the papers:
Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families
by M. Nicoletti et al. *PloS ONE*, 19(3): e0298105.
[https://doi.org/10.1371/journal.pone.0298105](https://doi.org/10.1371/journal.pone.0298105)

The repository contains python codes and NEURON `.mod` files for Hodgkin-Huxley models of
AVAL, AVAR, VA5, VB6, VD5, AIY, and RIM C.elegans neurons. 

The `.mod` files allow to model 22 ionic currents 
and the intracellular calcium. 

The Python files are organized for each neuron (AVAL, AVAR, AIY, RIM, VA5, VB6, VD5) as follows:
1. file for simulating voltage and current clamp responses entitled "`NeuronName_simulation.py`"
2.two files containing the functions for voltage and current clamp protocols entitled
"`NeuronName_simulation_vclamp.py`" and "`NeuronName_simulation_iclamp.py`", respectively

To reproduce the WT whole-cell behavior:
1. compile the NEURON `.mod` files in the same folder of the python codes
2. excute the file "`NeuronName_simulation.py`"

To simulate knock-out responses set to zero the conductance of the corresponding current.