TITLE I-h channel : Modelled from Rugiero et al 2002, J Physiol 538:2, p447 : Written by Jordan Chambers (jordandchambers@gmail.com) UNITS { (mA) = (milliamp) (mV) = (millivolt) } PARAMETER { v (mV) eih = -38 (mV) celsius (degC) gbar = 1e-4 (mho/cm2) vhalf = -72 (mV) vslope1 = 8.2 (mV) vslope2 = 11.9 (mV) tmc1 = 537 (ms) tmc2 = 56 (ms) q10 = 4.5 :guessed from other Ih studies at similar temperatures jtmc = 1 (1) jiih (mA/cm2) } NEURON { SUFFIX ih NONSPECIFIC_CURRENT i GLOBAL gbar, vhalf, vslope1, vslope2, tmc1, tmc2, linf, taul RANGE jiih THREADSAFE linf, taul } STATE { l } ASSIGNED { i (mA/cm2) linf taul ghd } INITIAL { rate(v) l=linf } BREAKPOINT { SOLVE states METHOD cnexp ghd = gbar*l i = ghd*(v-eih) jiih = i } DERIVATIVE states { rate(v) l' = (linf - l)/taul } PROCEDURE rate(v (mV)) { LOCAL a,qt qt=q10^((celsius-34)/10) linf = 1/(1 + exp((v - vhalf)/vslope1)) taul = jtmc*(tmc1 + (qt*tmc2/(exp((v-vhalf)/vslope2) + exp(-(v-vhalf)/vslope2)))) }