TITLE HVA (L-type) calcium channel with low threshold for activation (dendrites) COMMENT Used in distal dendrites to account for distally restricted initiation of Ca++ spikes. Uses channel conductance (not permeability). Written by Yiota Poirazi, 1/8/00 poirazi@LNC.usc.edu. ENDCOMMENT NEURON { SUFFIX calH USEION ca READ eca WRITE ica RANGE gcalbar, ica } UNITS { (mA) = (milliamp) (mV) = (millivolt) (S) = (siemens) } PARAMETER { :parameters that can be entered when function is called in cell-setup gcalbar = 0 (S/cm2) : initialized conductance } ASSIGNED { :parameters needed to solve DE v (mV) celsius (degC) ica (mA/cm2) eca (mV) : Ca2+ reversal potential minf (1) hinf (1) taum (ms) tauh (ms) } STATE { :unknown activation and inactivation parameters to be solved in the DEs m h } BREAKPOINT { SOLVE states METHOD cnexp ica = gcalbar*pow(m, 3)*h*(v - eca) } DERIVATIVE states { rates (v) m' = (minf-m)/taum h' = (hinf-h)/tauh } INITIAL { rates(v) m = minf :initial activation parameter value h = hinf :initial inactivation parameter value } PROCEDURE rates(v (mV)) { minf = 1 / (1 + exp(-(v+37(mV))/1(mV))) :Ca activation taum = 3.6 hinf = 1 / (1 + exp((v+41(mV))/0.5(mV))) :Ca inactivation tauh = 29 }