This NEURON model of a dentate granule cell is associated with the
following paper:

Pedro Mateos-Aparicio, Ricardo Murphy and Johan F. Storm (2014).
Complementary functions of SK and Kv7/M potassium channels in
excitability control and synaptic integration in rat hippocampal
dentate granule cells. Journal of Physiology 592, 669-693.

It is based on the model of Aradi & Holmes (1999; Journal of
Computational Neuroscience 6, 215-235) which uses an idealized
morphology (DGC_Morphology.hoc). The model was used to help understand
the contribution of M and SK channels to the medium
afterhyperpolarization (mAHP) following one or seven spikes, as well
as the contribution of M channels to the slow afterhyperpolarization
(sAHP). We found that SK channels are the main determinants of the
mAHP, in contrast to CA1 pyramidal cells where the mAHP is primarily
caused by the opening of M channels. The model reproduced these
experimental results, but we were unable to reproduce the effects of
the M-channel blocker XE991 on the sAHP. It is suggested that either
the XE991- sensitive component of the sAHP is not due to M channels,
or that when contributing to the sAHP, these channels operate in a
mode different from that associated with the mAHP.

After compiling the .mod files, run the program mosinit.hoc. Two
panels will appear. Click on "Figure 6A" or "Figure 6B" in the smaller
panel to reproduce the corresponding figures in the paper (details in
DGC_Figures.hoc). 




The larger panel:

allows you to inject a test pulse into the soma and change various
model parameters (see DGC_Biophysics.hoc, DGC_Parameters.hoc,
DGC_SetUp.hoc, the .mod files and our paper's supplementary
information for details).