Model files in the NEURON simulation environment (v8.0.0) from the paper:
"T-type Ca 2+ and persistent Na + currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability. ”
By Aleksandra Topczewska 1 , Elisabetta Giacalone 2 , Wendy S. Pratt 3 , Michele Migliore 2 , Annette C. Dolphin 3 and Mala M. Shah 1* . 1 Pharmacology, School of Pharmacy, University College London, WC1N 4AX UK; 2 Institute of Biophysics, National Research Council, 90146 Palermo, Italy; 3 Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT, UK.
Auto-launch from ModelDB or:
Compile the mod files with mknrndll (mswin or graphical mac) or nrnivmodl (unix/linux)). Start the simulation by (unix/linux) typing on the command line:
nrngui mosinit.hoc
or (mac os x) drag and dropping the mosinit.hoc file on the nrngui icon or (mswin) double clicking on the mosinit.hoc file.
mosinit.hoc will reproduce the simulated traces in Fig.5 of the paper.
Click on buttons "50pA", "100pA", "200pA", "250pA" to run the simulations at different current injection in all the conditions:
- Control (black line)