Model files in the NEURON simulation environment (v8.0.0) from the paper:

Spoleti, E., Krashia, P., La Barbera, L., Nobili, A., Lupascu, C. A., Giacalone, E., Keller, F., Migliore, M., Renzi, M., & D'Amelio, M. (2021). Early derailment of firing properties in CA1 pyramidal cells of the ventral hippocampus in an Alzheimer's disease mouse model. Experimental neurology, 350, 113969. Advance online publication. https://doi.org/10.1016/j.expneurol.2021.113969

Auto-launch from ModelDB or:

Compile the mod files with mknrndll (mswin or graphical mac) or nrnivmodl (unix/linux)). Start the simulation by (unix/linux) typing on the command line:

nrngui mosinit.hoc

or (mac os x) drag and dropping the mosinit.hoc file on the nrngui icon or (mswin) double clicking on the mosinit.hoc file.

mosinit.hoc will reproduce the simulated traces in Fig.5 of the paper:

- The"WT 3m 0.25nA" and 'WT 3m 0.5nA" buttons reproduce the 3-months WT cell's trace at 0.25nA and 0.5nA respectively, in fig.5A.

- The "TG 3m 0.25nA" and 'TG 3m 0.5nA" buttons reproduce the 3-months TG cell's trace at 0.25nA and 0.5nA respectively, in fig.5A.

- The "WT 8m 0.2nA" and 'WT 8m 0.25nA" buttons reproduce the 8-months WT cell's trace at 0.2nA and 0.25nA respectively, in fig.5B.

- The "TG 8m 0.2nA" and 'TG 8m 0.25nA" buttons reproduce the 8-months TG cell's trace at 0.2nA and 0.25nA respectively, in fig.5B.

Questions on how to use this model should be directed to elisabetta.giacalone@ibf.cnr.it or carmen.lupascu@ibf.cnr.it

If you need more help running the model on your platform, please consult this page:

https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml