The provided code is designed to model the electrical behavior of neurons, focusing on the ionic currents that contribute to action potential generation and propagation. Below are the key biological elements and their relevance to the code:
EREST_ACT): This represents the baseline electrical charge of a neuron when it is not firing. The value is set to -70 mV, which is typical for many types of neurons.The code defines prototypes for various ion channels, each contributing to the dynamics of neuronal action potentials:
Sodium (Na(^+)) Channels:
make_NaF15: Models the fast transient sodium channel, crucial for the rapid depolarization phase of the action potential.make_NaP15: Models the persistent non-inactivating sodium channel, contributing to sustained depolarization and neuronal excitability.Potassium (K(^+)) Channels:
make_KDR15: Models the delayed rectifier potassium channel, important for repolarizing the membrane following an action potential.make_KA15: Models the transient potassium channel, which helps regulate post-spike potentials and firing frequency.make_K215: Models a slow activating/inactivating potassium channel, adding to the diversity of repolarizing currents.make_KM15: Models the muscarinic receptor-suppressed potassium channel, which is involved in modulating neuronal excitability through neurotransmitter signaling.Calcium (Ca(^2+)) Channels:
make_CaL15: Models low threshold transient calcium channels, which open with slight depolarization and contribute to subthreshold activity.make_CaH15: Models high threshold transient calcium channels, which require significant depolarization to activate and contribute to action potential dynamics.make_Ca_s15, make_Ca_d15): These elements model the dynamics of intracellular calcium concentration changes due to calcium influx during neuronal activity.make_KCs15 and make_KCd15: Reflects calcium-dependent potassium channels which serve to provide feedback in response to calcium influx, affecting neuronal excitability and afterhyperpolarization.make_KAHPs15 and make_KAHPd15: Related to the afterhyperpolarization phase that follows an action potential, further contributing to neuronal firing patterns.make_AR15: Models the anomalous rectifier channel, which is involved in stabilizing the neuron's resting membrane potential and contributing to subthreshold activities.include synchansC23FS.g): Though not detailed here, these are likely included to model synaptic inputs that affect the neuron's firing rate.include protospikeC23FS.g): This part of the code likely deals with generating action potentials upon reaching the threshold potential.Overall, this code forms part of a comprehensive model aiming to simulate neuronal behavior by incorporating a variety of ion channels and dynamic processes that are foundational to understanding neuronal physiology.