The provided code is a computational model aimed at understanding the dynamics of the hyperpolarization-activated inward current, commonly referred to as the (I_h) current, in a neuronal context. Here's a detailed description of the biological basis:
a
with a length and diameter of 20 µm. This simplification allows the focus to be on ion channel dynamics without the complexities of multicompartmental interactions.Ra=150 Ω·cm
), membrane capacitance (cm=1 µF/cm²
), and a leak conductance (g_pas=0.0001 S/cm²
).ih
mechanism, indicating a specific interest in modeling the (I_h) current.eh_ih=-43 mV
) and the conductance density (ghbar_ih
), which is manipulated in the code to study different conditions.Steady-State Activation & Time Constants:
rinf_ih
) and time constants (rtau_ih
) of (I_h) against membrane potential, emulating biological experiments assessing voltage-dependent activation properties.Artificial Current Injection & Voltage Clamp:
IClamp
) and voltage clamp (SEClamp
) methods simulate experimental protocols for studying (I_h) under controlled conditions.Temperature Control:
Temporal Dynamics:
dt=0.1 ms
) and total simulation time (tstop=100 ms
or tstop=1000 ms
) are chosen to capture the dynamic changes accurately in (I_h) activity.By modeling these specific aspects, the code allows for exploration of (I_h) channel behavior, contributing to a broader understanding of its physiological role in neural dynamics.