The code is part of a computational neuroscience model aimed at simulating and analyzing the behavior of neurons in response to extracellular stimuli and the resulting extracellular potentials. It extends the NEURON simulation environment by introducing the xtra
mechanism, which is specifically designed to be used alongside the extracellular mechanism. The primary biological context involves the interaction between neurons and their surrounding environment, particularly focusing on extracellular electrical stimuli and recordings.
Extracellular Stimulation and Recording:
Vector
in hoc) to be applied across the neuronal membrane. This mimics how an electric field or current can be applied externally to stimulate neural activity.Neuron-electrode Interaction:
rx
represents the transfer resistance between the stimulating or recording electrode and the neuron. This reflects the physical and electrical properties that influence signal transmission between the electrode and the neuron.Membrane Current Contribution:
i_membrane
) on the extracellular potential, labeled er
. This involves calculating how currents across the neuronal membrane contribute to potential changes that could be recorded extracellularly.Spatial Considerations:
x, y, z
), which are used to interpolate the location of membrane elements from the 3D structure of the neuron. This is crucial for accurately modeling how signals disperse from specific points in the neuron to recording and stimulating sites.Overall, the code represents a bridge between computational modeling and experimental neuroscience, facilitating the exploration of how neurons interact with and respond to their electrochemical environment.