The code provided is part of a computational model in neuroscience, focusing on simulating synaptic conductances and their time courses within a neuronal network. Here's the biological basis of the code: ### Biological Background 1. **Synaptic Conductance**: - The code models synaptic conductances, `gpe` and `gpi`, which are representative of excitatory and inhibitory postsynaptic potentials, respectively. These conductances are key to understanding how neurons integrate inputs and produce an output signal or action potential. - Excitatory synapses typically involve neurotransmitters like glutamate acting on receptors that allow cations such as Na⁺ and Ca²⁺ to flow into the neuron, leading to depolarization. - Inhibitory synapses, on the other hand, often involve neurotransmitters like GABA (gamma-aminobutyric acid) acting on receptors that allow the flow of anions such as Cl⁻, leading to hyperpolarization. 2. **Gaussian Distribution of Synaptic Inputs**: - Conductances `gpe` and `gpi` are calculated using a Gaussian function, suggesting a spatial distribution of synaptic strength or a representation of heterogeneous synaptic input across a spatial continuum (e.g., a dendrite or neuronal field). - Parameters `mu_e` and `mu_i` represent the mean positions of excitatory and inhibitory synaptic inputs, `sigma_e` and `sigma_i` represent the width of the input distribution, and `a_e` and `a_i` are the amplitudes or maximum conductance values. 3. **Temporal Dynamics**: - The code features time constants `taur_e`, `taud_e`, `taur_i`, and `taud_i`, representing the rise and decay times of the synaptic conductances. These parameters are crucial for modeling the temporal dynamics of synaptic transmission. - The use of `tvec`, `t0`, and `t1` suggests a preference for simulating the conductance changes over time, capturing the kinetics of synaptic transmission. 4. **Spatial Selection and Activation**: - The model selectively activates specific sections of a neuronal structure (`selected_section_e` and `selected_section_i`), implying a consideration for spatial specificity in synaptic activation—aligning with the anatomical reality where certain parts of neurons can be more synaptically active, dependent on their synaptic inputs. - Activations are conditional based on the spatial conditions (`x_star`, `x_bound_val`), indicating a structured approach to stimuli propagation within this network, possibly mimicking sensory input or feedback mechanisms. 5. **Relevance Duration**: - The `rel_dur` parameter modulates the duration for which inhibitory synapses remain active if `zero_inhib` is not set, reflecting a scenario where active inhibition is either persistent or transient based on simulated conditions. ### Summary Overall, the code simulates the complex spatiotemporal dynamics of synaptic conductances in a neural network, capturing the intricacies of excitatory and inhibitory interactions within specific neuronal regions. It models how neurons receive, process, and respond to synaptic inputs, which is foundational to understanding neural computation and communication in the brain.