The code provided is a model of the NaV1.1 sodium channel, a voltage-gated sodium channel subtype. This type of channel plays a critical role in the initiation and propagation of action potentials in neurons. Specifically, the code models the dynamics of this channel's fast activation and inactivation kinetics as they relate to sodium ion (Na+) conductance.
NaV1.1 Channel
Gating Variables and Kinetics
m
, which represents the probability of the channel being in an open state. Activation is governed by two parameters: mh
(half-activation voltage) and ms
(activation slope), indicating how voltage changes affect the channel's probability of opening.h
, this describes the probability of the channel transitioning to an inactive state where it can't be activated until it returns to rest. It's controlled by hh
(half-inactivation voltage) and hs
(inactivation slope).Ion Currents and Conductance
gNav11
) and the driving force (difference between membrane voltage v
and Nernst potential for sodium ena
).gNav11bar
, a parameter that indicates the density of functional NaV1.1 channels per unit area of membrane.Temperature Adjustment
qt
in the code), reflecting the biological reality that ion channel kinetics are temperature-dependent.Tetrodotoxin (TTX) Block
ttxi
and ttxo
) is present, setting mInf
(activation steady state) to zero.This code models the electrophysiological characteristics of NaV1.1 sodium channels, emphasizing their role in neuronal excitability and the modulation of their kinetics by external factors such as temperature and TTX. The use of biophysical parameters allows for simulations that reflect the dynamic behavior of these channels under various physiological and experimental conditions.