The code provided appears to model various aspects of neuronal dynamics, focusing on the biophysical processes underlying neuronal excitability and firing behavior. The biological basis of the model can be summarized as follows:
V
, which represents the electrical state of the neuron's membrane.Cai
, which is crucial in various cellular functions, including synaptic activity and signal transduction. The calcium reversal potential ECa
is calculated using the Nernst equation, which considers extracellular Caout
and intracellular calcium concentrations along with temperature and constants such as the universal gas constant R
and Faraday's constant F
.m_Ca
) and Inactivation (h_Ca
) Variables: These gating variables for calcium channels play a critical role in the opening and closing states of the channels in response to changes in membrane potential.mTRP
and h_GLTest
variables appear to represent the activation and inactivation states of TRP channels, which are involved in calcium and sodium influx, affecting neuronal excitability.TK
(converted to Celsius as TC
) influences the dynamics of the model. Temperature can modulate the rates of ion channel gating and other cellular processes. The model seems to employ a Q10 coefficient ro
to adjust biophysical processes according to temperature changes.spikeTime
) and calculating the inter-spike intervals (ISI
). This informs the firing frequency Frequency
and mean firing rate MF
, central to understanding neuron response patterns.FRbin
is calculated over time bins to visualize how frequently the neuron fires over time. This is crucial for understanding the neuron's response to ongoing stimuli or conditions.The code visualizes several key aspects of the model:
Overall, the model simulates neuronal excitability by incorporating the effects of ionic currents, particularly calcium, and temperature-dependent processes on membrane potential dynamics and firing patterns. This simulation assists in understanding how changes in these parameters can affect neuronal behavior, potentially reflecting conditions like temperature shifts and channelopathies affecting TRP or voltage-gated calcium channels.